Overview
This entry, listed under Orphanet code 183716, refers to a group of complex primary immunodeficiency syndromes that have since been reclassified or merged into more specific disease categories. Primary immunodeficiencies are conditions where the immune system does not work properly from birth, making the body less able to fight infections. People with these conditions often get frequent, severe, or unusual infections that healthy individuals would normally fight off easily. The term 'complex syndrome of primary immunodeficiency' was used as a broad grouping for conditions where immune system problems occurred alongside other features affecting multiple body systems, such as growth problems, skin abnormalities, developmental delays, or organ malformations. Because this classification is now obsolete, patients who were previously grouped under this label have likely been reassigned to more specific diagnoses as medical understanding has improved. If you or a family member was given this diagnosis, it is important to work with a clinical immunologist or geneticist to determine the precise underlying condition. Modern genetic testing can now identify the specific gene changes responsible for many primary immunodeficiencies, which helps guide treatment more effectively. Treatments for primary immunodeficiencies generally include immunoglobulin replacement therapy, preventive antibiotics, and in some cases bone marrow or stem cell transplantation. The exact treatment depends on the specific type of immunodeficiency identified.
Key symptoms:
Frequent or severe infectionsInfections that are hard to treat or keep coming backUnusual infections caused by organisms that rarely affect healthy peoplePoor growth or failure to thrive in childrenSkin rashes or skin problemsDelayed development or intellectual disabilityEnlarged lymph nodes or spleenChronic diarrhea or digestive problemsAutoimmune problems where the body attacks its own tissuesAbnormal facial features or body structure differencesLow blood cell countsChronic lung infections or bronchiectasis
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsMeyer Children's Hospital IRCCS — NA
University Hospital, Montpellier
Qu Biologics Inc. — PHASE2
Icahn School of Medicine at Mount Sinai
GC Biopharma Corp — PHASE3
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — PHASE2
Washington University School of Medicine — PHASE2
National Institute of Allergy and Infectious Diseases (NIAID) — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Other complex syndrome of primary immunodeficiency.
10 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Other complex syndrome of primary immunodeficiency.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Other complex syndrome of primary immunodeficiency.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Can you identify the specific type of primary immunodeficiency I or my child has?,What genetic testing should be done to get a more precise diagnosis?,Will immunoglobulin replacement therapy be needed, and if so, how often?,Are there any vaccines that should be avoided?,What signs of infection should prompt an emergency room visit?,Is bone marrow transplantation or gene therapy an option for this condition?,Should other family members be tested for this condition?
Common questions about OBSOLETE: Other complex syndrome of primary immunodeficiency
What is OBSOLETE: Other complex syndrome of primary immunodeficiency?
This entry, listed under Orphanet code 183716, refers to a group of complex primary immunodeficiency syndromes that have since been reclassified or merged into more specific disease categories. Primary immunodeficiencies are conditions where the immune system does not work properly from birth, making the body less able to fight infections. People with these conditions often get frequent, severe, or unusual infections that healthy individuals would normally fight off easily. The term 'complex syndrome of primary immunodeficiency' was used as a broad grouping for conditions where immune system p
Are there clinical trials for OBSOLETE: Other complex syndrome of primary immunodeficiency?
Yes — 10 recruiting clinical trials are currently listed for OBSOLETE: Other complex syndrome of primary immunodeficiency on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.