Overview
Neurosensory deafness-pituitary dwarfism syndrome, also known as sensorineural hearing loss with pituitary dwarfism, is an extremely rare genetic condition that combines two main problems: hearing loss caused by nerve damage in the inner ear (sensorineural deafness) and short stature caused by the pituitary gland not producing enough growth hormone (pituitary dwarfism). The pituitary gland is a small gland at the base of the brain that controls growth and many other body functions. When it does not work properly, children may grow much more slowly than expected. The hearing loss in this condition affects the nerves that carry sound signals from the ear to the brain, which is different from hearing loss caused by ear infections or structural problems in the outer ear. This condition is now listed as 'obsolete' in medical databases, meaning it may have been reclassified or merged with another diagnosis as medical understanding has advanced. Very few cases have been described in the medical literature. Treatment typically focuses on managing each symptom separately — hearing aids or cochlear implants for hearing loss, and growth hormone replacement therapy for short stature. Early diagnosis and intervention are important to support normal development in affected children.
Also known as:
Key symptoms:
Hearing loss present from birth or early childhoodSignificantly short stature compared to peersSlow growth rate during childhoodDelayed pubertyDifficulty hearing speech, especially in noisy environmentsDelayed speech and language developmentLow levels of growth hormonePossible delayed bone maturationSmall body proportions consistent with growth hormone deficiency
Autosomal recessive
Passed on when both parents carry the same gene change; often skips generations
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific hormone deficiencies does my child have, and how will they be treated?,How often will my child need growth hormone injections, and what is the expected improvement in height?,What type of hearing loss does my child have, and would hearing aids or cochlear implants be more appropriate?,Should we pursue genetic testing, and what would the results mean for our family?,What school accommodations should we request to support my child's learning?,How often should we schedule follow-up appointments with the endocrinologist and audiologist?,Are there other pituitary hormones we should monitor over time?
Common questions about OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome
What is OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome?
Neurosensory deafness-pituitary dwarfism syndrome, also known as sensorineural hearing loss with pituitary dwarfism, is an extremely rare genetic condition that combines two main problems: hearing loss caused by nerve damage in the inner ear (sensorineural deafness) and short stature caused by the pituitary gland not producing enough growth hormone (pituitary dwarfism). The pituitary gland is a small gland at the base of the brain that controls growth and many other body functions. When it does not work properly, children may grow much more slowly than expected. The hearing loss in this condit
How is OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome inherited?
OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome follows a autosomal recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome typically begin?
Typical onset of OBSOLETE: Neurosensory deafness-pituitary dwarfism syndrome is childhood. Age of onset can vary across affected individuals.