Overview
McLain-Dekaban syndrome is a very rare condition that is now considered an obsolete or historical diagnostic label in modern medical classification. It was originally described as a syndrome involving a combination of neurological problems and physical abnormalities present from birth or early childhood. Because this diagnosis has been retired or reclassified, it may overlap with or have been absorbed into other better-defined conditions recognized today. The exact features attributed to McLain-Dekaban syndrome historically included intellectual disability, abnormalities of the nervous system, and certain physical differences, but the boundaries of this diagnosis were never firmly established in the medical literature. Because this is an obsolete classification, people who were previously given this diagnosis may now be reclassified under a more specific condition using modern genetic testing. If you or a family member carries this historical diagnosis, it is strongly recommended to seek re-evaluation by a clinical geneticist. Advances in genetic testing, such as whole exome or genome sequencing, may now provide a more precise and actionable diagnosis that could open doors to better-targeted care and support.
Key symptoms:
intellectual disabilitydevelopmental delaysneurological abnormalitiesphysical differences present from birthpossible movement or coordination problems
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: McLain-Dekaban syndrome.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: McLain-Dekaban syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: McLain-Dekaban syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is McLain-Dekaban syndrome still a recognized diagnosis, and should we pursue re-evaluation?,What modern genetic tests could help identify a more specific underlying condition?,Are there other conditions that look similar to what was historically called McLain-Dekaban syndrome?,What therapies or support services are available based on the symptoms present?,Should other family members be evaluated or tested?,Are there any clinical registries or research studies we could participate in?,How can we connect with other families who may have received this historical diagnosis?
Common questions about OBSOLETE: McLain-Dekaban syndrome
What is OBSOLETE: McLain-Dekaban syndrome?
McLain-Dekaban syndrome is a very rare condition that is now considered an obsolete or historical diagnostic label in modern medical classification. It was originally described as a syndrome involving a combination of neurological problems and physical abnormalities present from birth or early childhood. Because this diagnosis has been retired or reclassified, it may overlap with or have been absorbed into other better-defined conditions recognized today. The exact features attributed to McLain-Dekaban syndrome historically included intellectual disability, abnormalities of the nervous system,
At what age does OBSOLETE: McLain-Dekaban syndrome typically begin?
Typical onset of OBSOLETE: McLain-Dekaban syndrome is childhood. Age of onset can vary across affected individuals.