OBSOLETE: McLain-Dekaban syndrome

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ORPHA:2474
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Overview

McLain-Dekaban syndrome is a very rare condition that is now considered an obsolete or historical diagnostic label in modern medical classification. It was originally described as a syndrome involving a combination of neurological problems and physical abnormalities present from birth or early childhood. Because this diagnosis has been retired or reclassified, it may overlap with or have been absorbed into other better-defined conditions recognized today. The exact features attributed to McLain-Dekaban syndrome historically included intellectual disability, abnormalities of the nervous system, and certain physical differences, but the boundaries of this diagnosis were never firmly established in the medical literature. Because this is an obsolete classification, people who were previously given this diagnosis may now be reclassified under a more specific condition using modern genetic testing. If you or a family member carries this historical diagnosis, it is strongly recommended to seek re-evaluation by a clinical geneticist. Advances in genetic testing, such as whole exome or genome sequencing, may now provide a more precise and actionable diagnosis that could open doors to better-targeted care and support.

Also known as:

Key symptoms:

intellectual disabilitydevelopmental delaysneurological abnormalitiesphysical differences present from birthpossible movement or coordination problems

Age of Onset

Childhood

Begins in childhood, roughly ages 1 to 12

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: McLain-Dekaban syndrome.

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No actively recruiting trials found for OBSOLETE: McLain-Dekaban syndrome at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the OBSOLETE: McLain-Dekaban syndrome community →

No specialists are currently listed for OBSOLETE: McLain-Dekaban syndrome.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: McLain-Dekaban syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about OBSOLETE: McLain-Dekaban syndrome

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

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Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Is McLain-Dekaban syndrome still a recognized diagnosis, and should we pursue re-evaluation?,What modern genetic tests could help identify a more specific underlying condition?,Are there other conditions that look similar to what was historically called McLain-Dekaban syndrome?,What therapies or support services are available based on the symptoms present?,Should other family members be evaluated or tested?,Are there any clinical registries or research studies we could participate in?,How can we connect with other families who may have received this historical diagnosis?

Common questions about OBSOLETE: McLain-Dekaban syndrome

What is OBSOLETE: McLain-Dekaban syndrome?

McLain-Dekaban syndrome is a very rare condition that is now considered an obsolete or historical diagnostic label in modern medical classification. It was originally described as a syndrome involving a combination of neurological problems and physical abnormalities present from birth or early childhood. Because this diagnosis has been retired or reclassified, it may overlap with or have been absorbed into other better-defined conditions recognized today. The exact features attributed to McLain-Dekaban syndrome historically included intellectual disability, abnormalities of the nervous system,

At what age does OBSOLETE: McLain-Dekaban syndrome typically begin?

Typical onset of OBSOLETE: McLain-Dekaban syndrome is childhood. Age of onset can vary across affected individuals.