Overview
Intellectual disability-unusual facies, Davis-Lafer type is an extremely rare condition that was originally described in the medical literature and cataloged in rare disease databases. The term 'OBSOLETE' in its name means that this diagnosis is no longer considered a distinct or active disease category in current medical classifications. It was historically described as a condition involving intellectual disability (difficulty with learning, reasoning, and problem-solving) along with unusual facial features. The condition was named after the clinicians Davis and Lafer who first reported it. Because this condition has been marked as obsolete, it is possible that affected individuals have since been reclassified under a different, more precisely defined genetic syndrome as medical knowledge and genetic testing have advanced. Many older syndrome descriptions from earlier decades have been absorbed into better-understood diagnoses once the underlying genetic cause was identified. If you or a family member was given this diagnosis in the past, it is strongly recommended to seek a re-evaluation by a clinical geneticist who can use modern genetic testing tools such as chromosomal microarray or whole exome sequencing to arrive at a more specific and current diagnosis. A more precise diagnosis can open doors to better management, prognosis information, and potential treatments or clinical trials.
Also known as:
Key symptoms:
Intellectual disabilityUnusual facial featuresDevelopmental delaysDifficulty with learning and reasoningPossible speech and language delays
Variable
Can be inherited in different ways depending on the underlying gene
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type at this time.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Since this diagnosis is now considered obsolete, what updated genetic testing should we pursue?,Could my child's symptoms fit a more specific or recently identified genetic condition?,What early intervention services would be most beneficial right now?,Are there any clinical trials or research studies we should consider?,What specialists should be part of our care team?,What is the expected developmental trajectory, and how can we best support progress?,Are there any associated medical problems we should screen for?
Common questions about OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type
What is OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type?
Intellectual disability-unusual facies, Davis-Lafer type is an extremely rare condition that was originally described in the medical literature and cataloged in rare disease databases. The term 'OBSOLETE' in its name means that this diagnosis is no longer considered a distinct or active disease category in current medical classifications. It was historically described as a condition involving intellectual disability (difficulty with learning, reasoning, and problem-solving) along with unusual facial features. The condition was named after the clinicians Davis and Lafer who first reported it.
At what age does OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type typically begin?
Typical onset of OBSOLETE: Intellectual disability-unusual facies, Davis-Lafer type is childhood. Age of onset can vary across affected individuals.