Overview
Hypodermyiasis (also called hypodermosis or warble fly infestation) is a parasitic condition caused by the larvae of botflies, most commonly from the genus Hypoderma. These flies lay their eggs on the skin or hair of a host — usually cattle or other large animals — but humans can occasionally become accidental hosts. When this happens in people, it is sometimes called human hypodermyiasis or accidental myiasis. After the eggs hatch, the tiny larvae burrow under the skin and migrate through the body's tissues, causing painful swelling, skin lumps, and a creeping sensation under the skin. In humans, the larvae typically cause a moving, swollen lump under the skin that may feel like something is crawling beneath the surface. The condition can also affect deeper tissues, including muscles and, in rare cases, the eye or nervous system, which can be more serious. Symptoms include itching, pain, and visible skin lesions. Note: This condition is marked as 'obsolete' in the Orphanet rare disease database, meaning it may have been reclassified, merged with a broader category of myiasis, or removed from active rare disease tracking. Treatment usually involves surgical removal of the larvae or antiparasitic medications. Most cases in humans resolve fully with prompt treatment.
Key symptoms:
A moving lump or swelling under the skinItching or burning sensation at the site of infestationFeeling of something crawling under the skinPainful skin nodules or boil-like lesionsRedness and inflammation around the affected areaSkin track marks or tunnels visible under the surfaceSwelling that changes location over days or weeksEye pain or vision problems if larvae migrate to the eyeNeurological symptoms such as headache or weakness if larvae reach the nervous systemGeneral discomfort or mild fever in some cases
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Hypodermyiasis.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Hypodermyiasis.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Hypodermyiasis.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How do you confirm that this is hypodermyiasis and not another skin condition?,What is the safest way to remove the larva in my case — surgery or medication?,Are there any signs I should watch for that would mean the larva has moved deeper into my body?,How long will it take to recover after treatment, and will there be any lasting effects?,Do I need any follow-up tests or imaging to make sure all larvae have been removed?,Is there any risk to people I live with, or is this condition not contagious between people?,What can I do to prevent this from happening again if I continue to work with or around cattle?
Common questions about OBSOLETE: Hypodermyiasis
What is OBSOLETE: Hypodermyiasis?
Hypodermyiasis (also called hypodermosis or warble fly infestation) is a parasitic condition caused by the larvae of botflies, most commonly from the genus Hypoderma. These flies lay their eggs on the skin or hair of a host — usually cattle or other large animals — but humans can occasionally become accidental hosts. When this happens in people, it is sometimes called human hypodermyiasis or accidental myiasis. After the eggs hatch, the tiny larvae burrow under the skin and migrate through the body's tissues, causing painful swelling, skin lumps, and a creeping sensation under the skin. In hu