Overview
This entry, listed under the Orphanet code 443319, is marked as OBSOLETE and refers to a condition once described as 'HIV-related vulvovaginal cancer.' This means it was previously used to describe cancers of the vulva (the outer female genitalia) or vagina that occurred in people living with HIV (Human Immunodeficiency Virus). Because HIV weakens the immune system, people living with HIV have a higher risk of developing certain cancers, including those caused by the Human Papillomavirus (HPV), such as vulvar and vaginal cancers. This specific disease classification has since been retired or reorganized in medical databases. The underlying conditions it referred to — vulvar cancer and vaginal cancer in the context of HIV — are now typically classified and managed under broader cancer and HIV-related illness categories. Symptoms of vulvovaginal cancer can include unusual lumps or sores on the vulva or vagina, persistent itching or burning, abnormal bleeding not related to periods, and pain during sex or urination. Because this is an obsolete classification, patients and caregivers should speak with their doctors about current, up-to-date diagnostic categories. Treatment for vulvovaginal cancers generally includes surgery, radiation therapy, and sometimes chemotherapy, depending on the stage and location of the cancer. HIV management with antiretroviral therapy (ART) is also a critical part of care, as keeping the immune system strong can improve cancer treatment outcomes.
Key symptoms:
Unusual lumps, bumps, or warts on the vulva or vaginaPersistent itching, burning, or soreness in the genital areaAbnormal vaginal bleeding not related to menstrual periodsPain or discomfort during sexPain or burning when urinatingSkin color changes or thickening on the vulvaOpen sores or ulcers in the genital area that do not healSwollen lymph nodes in the groinUnusual vaginal discharge
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: HIV-related vulvovaginal cancer.
View clinical trials →Clinical Trials
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: HIV-related vulvovaginal cancer.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: HIV-related vulvovaginal cancer.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is this cancer related to my HIV, and how does my HIV status affect my treatment options?,What stage is my cancer, and what does that mean for my treatment and outlook?,Should I change or adjust my HIV antiretroviral therapy during cancer treatment?,What are the side effects of the recommended cancer treatments, and how can they be managed?,How often will I need follow-up appointments and screenings after treatment?,Are there clinical trials available for people living with HIV who have this type of cancer?,What support services — such as counseling, nutrition advice, or support groups — are available to me?
Common questions about OBSOLETE: HIV-related vulvovaginal cancer
What is OBSOLETE: HIV-related vulvovaginal cancer?
This entry, listed under the Orphanet code 443319, is marked as OBSOLETE and refers to a condition once described as 'HIV-related vulvovaginal cancer.' This means it was previously used to describe cancers of the vulva (the outer female genitalia) or vagina that occurred in people living with HIV (Human Immunodeficiency Virus). Because HIV weakens the immune system, people living with HIV have a higher risk of developing certain cancers, including those caused by the Human Papillomavirus (HPV), such as vulvar and vaginal cancers. This specific disease classification has since been retired or
At what age does OBSOLETE: HIV-related vulvovaginal cancer typically begin?
Typical onset of OBSOLETE: HIV-related vulvovaginal cancer is adult. Age of onset can vary across affected individuals.