Overview
This entry, listed under the Orphanet code 443304, is now marked as 'obsolete,' meaning it has been retired from active use as a separate disease classification. It referred to cancers of the oropharynx — the back of the throat, tonsils, soft palate, and base of the tongue — that develop in people living with HIV (Human Immunodeficiency Virus). Because HIV weakens the immune system, people living with HIV have a higher risk of developing certain cancers, including cancers in the mouth and throat area. These cancers are often linked to infection with Human Papillomavirus (HPV), which the weakened immune system struggles to control. Common names for this condition include HIV-associated oropharyngeal cancer and AIDS-related oropharyngeal cancer. Symptoms can include a persistent sore throat, difficulty swallowing, a lump in the neck, changes in voice, and mouth pain. Treatment typically follows the same approach as oropharyngeal cancer in the general population — surgery, radiation therapy, and chemotherapy — combined with antiretroviral therapy (ART) to manage HIV. Because this classification is now obsolete, patients and doctors are directed to use updated diagnostic categories. If you or someone you know is living with HIV and has concerns about throat or mouth symptoms, speaking with an HIV specialist and an oncologist is strongly recommended.
Key symptoms:
Persistent sore throat that does not go awayDifficulty or pain when swallowingA lump or swelling in the neckChanges in voice or hoarsenessEar pain without an obvious causeUnexplained weight lossMouth pain or sorenessA sore or ulcer in the back of the mouth that does not healCoughing up bloodFeeling like something is stuck in the throat
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: HIV-related oropharyngeal cancer.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: HIV-related oropharyngeal cancer at this time.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: HIV-related oropharyngeal cancer.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: HIV-related oropharyngeal cancer.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How does my HIV status affect my cancer treatment options and outcomes?,Will my antiretroviral medications interact with my cancer treatments?,Is my cancer HPV-related, and does that change my treatment plan?,What can I do to protect my immune system during cancer treatment?,Are there clinical trials available for people living with HIV who have this type of cancer?,What support services are available to help me manage both HIV and cancer care at the same time?,How often will I need monitoring after treatment is completed?
Common questions about OBSOLETE: HIV-related oropharyngeal cancer
What is OBSOLETE: HIV-related oropharyngeal cancer?
This entry, listed under the Orphanet code 443304, is now marked as 'obsolete,' meaning it has been retired from active use as a separate disease classification. It referred to cancers of the oropharynx — the back of the throat, tonsils, soft palate, and base of the tongue — that develop in people living with HIV (Human Immunodeficiency Virus). Because HIV weakens the immune system, people living with HIV have a higher risk of developing certain cancers, including cancers in the mouth and throat area. These cancers are often linked to infection with Human Papillomavirus (HPV), which the weaken
How is OBSOLETE: HIV-related oropharyngeal cancer inherited?
OBSOLETE: HIV-related oropharyngeal cancer follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: HIV-related oropharyngeal cancer typically begin?
Typical onset of OBSOLETE: HIV-related oropharyngeal cancer is adult. Age of onset can vary across affected individuals.