Overview
HIV-related Non-Hodgkin lymphoma (also called AIDS-related lymphoma or HIV-associated lymphoma) is a type of blood cancer that develops in people living with HIV, the virus that causes AIDS. When HIV weakens the immune system over time, the body becomes less able to control abnormal cell growth, which can lead to lymphoma — a cancer that starts in white blood cells called lymphocytes. These cancers tend to grow quickly and can spread to many parts of the body, including the brain, bone marrow, and digestive system. Common symptoms include swollen lymph nodes, unexplained weight loss, drenching night sweats, persistent fever, and extreme tiredness. Because HIV-related lymphoma often spreads widely before it is caught, symptoms can vary depending on which organs are affected. Treatment usually combines antiretroviral therapy (ART) to control HIV with chemotherapy to fight the lymphoma. Modern HIV treatment has greatly improved outcomes — people whose HIV is well-controlled respond much better to lymphoma treatment than in earlier decades. This condition is considered 'obsolete' as a separate Orphanet classification because it is now better understood as a complication of HIV rather than a standalone rare disease.
Key symptoms:
Swollen lymph nodes in the neck, armpits, or groin that do not go awayUnexplained weight lossDrenching night sweatsPersistent fever without an obvious infectionExtreme tiredness or fatigueAbdominal pain or swellingFeeling full quickly when eatingHeadaches or confusion (if lymphoma spreads to the brain)Chest pain or difficulty breathingNausea, vomiting, or changes in bowel habitsBone painSkin lumps or rashes in some subtypes
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
2 eventsNational Cancer Institute (NCI) — PHASE1
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: HIV-related Non-Hodgkin lymphoma.
2 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Specialists
View all specialists →No specialists are currently listed for OBSOLETE: HIV-related Non-Hodgkin lymphoma.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: HIV-related Non-Hodgkin lymphoma.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific type of Non-Hodgkin lymphoma do I have, and how does that affect my treatment options?,How will my HIV treatment change now that I also have lymphoma?,What chemotherapy regimen do you recommend, and what side effects should I expect?,Is my lymphoma potentially curable, or is the goal to control it long-term?,Are there clinical trials I might be eligible for?,How will we monitor whether the treatment is working?,What signs or symptoms should make me go to the emergency room right away?
Common questions about OBSOLETE: HIV-related Non-Hodgkin lymphoma
What is OBSOLETE: HIV-related Non-Hodgkin lymphoma?
HIV-related Non-Hodgkin lymphoma (also called AIDS-related lymphoma or HIV-associated lymphoma) is a type of blood cancer that develops in people living with HIV, the virus that causes AIDS. When HIV weakens the immune system over time, the body becomes less able to control abnormal cell growth, which can lead to lymphoma — a cancer that starts in white blood cells called lymphocytes. These cancers tend to grow quickly and can spread to many parts of the body, including the brain, bone marrow, and digestive system. Common symptoms include swollen lymph nodes, unexplained weight loss, drenchin
How is OBSOLETE: HIV-related Non-Hodgkin lymphoma inherited?
OBSOLETE: HIV-related Non-Hodgkin lymphoma follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: HIV-related Non-Hodgkin lymphoma typically begin?
Typical onset of OBSOLETE: HIV-related Non-Hodgkin lymphoma is adult. Age of onset can vary across affected individuals.
Are there clinical trials for OBSOLETE: HIV-related Non-Hodgkin lymphoma?
Yes — 2 recruiting clinical trials are currently listed for OBSOLETE: HIV-related Non-Hodgkin lymphoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.