Overview
HIV-related Hodgkin lymphoma (also called HIV-associated Hodgkin lymphoma or AIDS-related Hodgkin lymphoma) is a type of blood cancer that develops in people living with HIV, the virus that causes AIDS. Hodgkin lymphoma is a cancer of the lymphatic system — the network of tissues and organs that help fight infection. In people with HIV, a weakened immune system makes it easier for certain cancers, including Hodgkin lymphoma, to develop. The Epstein-Barr virus (EBV) also plays a role in many of these cases. The disease causes swollen lymph nodes, most often in the neck, armpits, or groin. People may also experience fever, drenching night sweats, and unexplained weight loss — a group of symptoms sometimes called 'B symptoms.' Fatigue and itchy skin are also common. Treatment typically combines chemotherapy regimens (such as ABVD — doxorubicin, bleomycin, vinblastine, and dacarbazine) with antiretroviral therapy (ART) to control HIV. With modern HIV treatment and cancer therapy, many people achieve remission. This condition is now considered an 'obsolete' classification in some medical coding systems because updated guidelines integrate it into broader Hodgkin lymphoma categories, but it remains a clinically important diagnosis for people living with HIV.
Key symptoms:
Swollen, painless lymph nodes in the neck, armpits, or groinFever that comes and goes without a clear causeDrenching night sweatsUnexplained weight lossExtreme tiredness or fatigueItchy skin all over the bodyCoughing or shortness of breath if lymph nodes in the chest are affectedFeeling full quickly or belly discomfort if lymph nodes in the abdomen are enlargedIncreased infections due to weakened immune systemPale skin or easy bruising if bone marrow is involved
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: HIV-related Hodgkin lymphoma.
View clinical trials →Clinical Trials
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: HIV-related Hodgkin lymphoma.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: HIV-related Hodgkin lymphoma.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What stage is my Hodgkin lymphoma, and what does that mean for my treatment options?,How will my HIV treatment change during chemotherapy, and will my antiretroviral medications interact with cancer drugs?,What is the goal of treatment — cure, remission, or controlling the disease?,What side effects should I watch for, and when should I call you or go to the emergency room?,Are there clinical trials I might be eligible for?,How will we know if the treatment is working, and what happens if it stops working?,What support services — such as social work, nutrition counseling, or mental health support — are available to me?
Common questions about OBSOLETE: HIV-related Hodgkin lymphoma
What is OBSOLETE: HIV-related Hodgkin lymphoma?
HIV-related Hodgkin lymphoma (also called HIV-associated Hodgkin lymphoma or AIDS-related Hodgkin lymphoma) is a type of blood cancer that develops in people living with HIV, the virus that causes AIDS. Hodgkin lymphoma is a cancer of the lymphatic system — the network of tissues and organs that help fight infection. In people with HIV, a weakened immune system makes it easier for certain cancers, including Hodgkin lymphoma, to develop. The Epstein-Barr virus (EBV) also plays a role in many of these cases. The disease causes swollen lymph nodes, most often in the neck, armpits, or groin. Peop
How is OBSOLETE: HIV-related Hodgkin lymphoma inherited?
OBSOLETE: HIV-related Hodgkin lymphoma follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: HIV-related Hodgkin lymphoma typically begin?
Typical onset of OBSOLETE: HIV-related Hodgkin lymphoma is adult. Age of onset can vary across affected individuals.