OBSOLETE: Congenital absence of both forearm and hand, bilateral

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:295095
Who is this for?
Show terms as
8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Congenital absence of both forearm and hand, bilateral, is a rare limb difference that is present at birth. In this condition, both arms are missing from the forearm down, meaning the hands and lower portions of both arms did not develop during pregnancy. This is sometimes called bilateral transverse upper limb deficiency or bilateral below-elbow amputation. The term 'OBSOLETE' in the official name means this specific classification code is no longer actively used in current medical databases, and the condition may now be categorized under broader limb reduction defect categories. This condition can occur on its own (isolated) or as part of a broader syndrome that affects other parts of the body. When it occurs in isolation, the rest of the child's health and development, including intelligence, is typically normal. The cause can vary — it may result from genetic factors, disruptions in blood flow during fetal development (vascular disruption), amniotic band syndrome (where strands of tissue wrap around developing limbs), or environmental exposures during pregnancy. In many cases, no specific cause is identified. Treatment focuses on maximizing function and independence. This typically involves prosthetic devices fitted early in life, occupational therapy, and adaptive equipment. Modern prosthetics range from body-powered devices to advanced myoelectric (muscle-controlled) prostheses. Many individuals with this condition lead full, active, and independent lives with appropriate support and adaptive strategies.

Also known as:

Key symptoms:

Absence of both hands from birthAbsence of both forearms from birthArms end at or near the elbow on both sidesDifficulty grasping or holding objectsDifficulty with self-care tasks like dressing and eatingPossible residual limb sensitivityPossible differences in arm length between the two sides

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: Congenital absence of both forearm and hand, bilateral.

View clinical trials →

No actively recruiting trials found for OBSOLETE: Congenital absence of both forearm and hand, bilateral at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the OBSOLETE: Congenital absence of both forearm and hand, bilateral community →

No specialists are currently listed for OBSOLETE: Congenital absence of both forearm and hand, bilateral.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: Congenital absence of both forearm and hand, bilateral.

Search all travel grants →NORD Financial Assistance ↗

Community

Open OBSOLETE: Congenital absence of both forearm and hand, bilateralForum →

No community posts yet. Be the first to share your experience with OBSOLETE: Congenital absence of both forearm and hand, bilateral.

Start the conversation →

Latest news about OBSOLETE: Congenital absence of both forearm and hand, bilateral

No recent news articles for OBSOLETE: Congenital absence of both forearm and hand, bilateral.

Follow this condition to be notified when news becomes available.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What is the likely cause of my child's limb difference, and should we pursue genetic testing?,At what age should my child be fitted for their first prosthesis, and what type do you recommend?,How often will prosthetics need to be replaced as my child grows?,What occupational therapy services are available to help my child develop independence?,Are there any associated conditions or syndromes we should screen for?,Can you connect us with other families or support groups for children with limb differences?,What school accommodations should we request to support my child's learning and participation?

Common questions about OBSOLETE: Congenital absence of both forearm and hand, bilateral

What is OBSOLETE: Congenital absence of both forearm and hand, bilateral?

Congenital absence of both forearm and hand, bilateral, is a rare limb difference that is present at birth. In this condition, both arms are missing from the forearm down, meaning the hands and lower portions of both arms did not develop during pregnancy. This is sometimes called bilateral transverse upper limb deficiency or bilateral below-elbow amputation. The term 'OBSOLETE' in the official name means this specific classification code is no longer actively used in current medical databases, and the condition may now be categorized under broader limb reduction defect categories. This condit

At what age does OBSOLETE: Congenital absence of both forearm and hand, bilateral typically begin?

Typical onset of OBSOLETE: Congenital absence of both forearm and hand, bilateral is neonatal. Age of onset can vary across affected individuals.