Overview
This condition is listed in Orphanet under the code 77303 as 'OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect.' The 'obsolete' label means that medical experts have reclassified or retired this specific diagnostic category. It was previously used to describe a subtype of Common Variable Immunodeficiency (CVID) where the problem originates inside the B cells themselves — the white blood cells responsible for making antibodies. Without enough working antibodies, the immune system cannot fight off infections properly. CVID as a broader condition causes the body to produce very low levels of protective antibodies (immunoglobulins). People with CVID-related conditions tend to get frequent, serious, or unusual infections — especially in the lungs, sinuses, and digestive system. Over time, repeated infections can damage organs, particularly the lungs. Because this specific subtype has been retired, patients who were previously given this diagnosis may now be classified under a more precise CVID subtype or a related primary immunodeficiency. If you have this diagnosis on your records, it is important to speak with an immunologist to confirm your current classification and ensure you are receiving the most up-to-date care. Treatment for CVID-related conditions typically involves regular immunoglobulin replacement therapy to boost the immune system.
Also known as:
Key symptoms:
Frequent or severe bacterial infections (such as pneumonia or sinus infections)Recurring ear infectionsChronic diarrhea or digestive problemsUnexplained weight lossSwollen lymph nodes or enlarged spleenFatigue and low energyAutoimmune problems (where the immune system attacks the body's own tissues)Inflammatory bowel-like symptomsIncreased risk of certain cancers, especially lymphomaSlow recovery from infections that most people shake off quickly
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect.
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Caregiver Resources
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Since this diagnosis is now listed as obsolete, what is my current correct diagnosis?,Which type of immunoglobulin replacement therapy is best for me — intravenous or subcutaneous?,How often do I need blood tests and lung function checks?,Are there any vaccines I should avoid or specifically get?,What signs of infection or complications should make me go to the emergency room?,Should I have genetic testing to find out if there is a specific gene causing my condition?,Are there any clinical trials I might be eligible for?
Common questions about OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect
What is OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect?
This condition is listed in Orphanet under the code 77303 as 'OBSOLETE: Common variable immunodeficiency due to an intrinsic B cell defect.' The 'obsolete' label means that medical experts have reclassified or retired this specific diagnostic category. It was previously used to describe a subtype of Common Variable Immunodeficiency (CVID) where the problem originates inside the B cells themselves — the white blood cells responsible for making antibodies. Without enough working antibodies, the immune system cannot fight off infections properly. CVID as a broader condition causes the body to pr