OBSOLETE: Combined hyperlipidemia

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ORPHA:79211
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Overview

Combined hyperlipidemia, also known as familial combined hyperlipidemia (FCH or FCHL) or mixed hyperlipidemia, is a condition where the blood contains too much of more than one type of fat (lipid). Specifically, people with this condition have high levels of cholesterol, triglycerides, or both circulating in their bloodstream. The term 'combined' refers to this mix of elevated fats. It is worth noting that this Orphanet entry is marked as 'obsolete,' meaning it has been reorganized into more specific diagnostic categories in current medical classification systems. This condition affects the way the body processes and clears fats after they are absorbed from food or made by the liver. Over time, these excess fats can build up inside blood vessel walls, making them narrower and harder. This raises the risk of serious heart and blood vessel problems, including heart attack and stroke. Common symptoms can be subtle at first. Many people feel no symptoms at all until a complication occurs. Some people develop fatty deposits under the skin or around the eyes (called xanthomas or xanthelasmas). The most important long-term risks are cardiovascular disease, including coronary artery disease. Treatment focuses on lifestyle changes such as a heart-healthy diet and regular exercise, combined with cholesterol-lowering medications when needed.

Also known as:

Key symptoms:

High cholesterol levels found on a blood testHigh triglyceride levels found on a blood testFatty yellowish deposits under the skin, especially around the elbows, knees, or buttocks (xanthomas)Yellowish deposits around the eyelids (xanthelasmas)Chest pain or pressure, especially with physical activityShortness of breathFatigue or low energyAbdominal pain (especially if triglycerides are very high)Cloudy or milky appearance of blood (in severe cases of high triglycerides)Early signs of heart disease

Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

FDA & Trial Timeline

4 events
Mar 2026

DEXMEDETOMIDINE HYDROCHLORIDE: New indication approved

FDAcompleted
Feb 2021

DEXMEDETOMIDINE HYDROCHLORIDE: New indication approved

FDAcompleted
Aug 2017

DEXMEDETOMIDINE HYDROCHLORIDE: New indication approved

FDAcompleted
Aug 2015

DEXMEDETOMIDINE HYDROCHLORIDE: FDA approved

FDAcompleted

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for OBSOLETE: Combined hyperlipidemia.

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No actively recruiting trials found for OBSOLETE: Combined hyperlipidemia at this time.

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No specialists are currently listed for OBSOLETE: Combined hyperlipidemia.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to OBSOLETE: Combined hyperlipidemia.

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Community

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Latest news about OBSOLETE: Combined hyperlipidemia

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Caregiver Resources

NORD Caregiver Resources

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Social Security Disability

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Questions for your doctor

Bring these to your next appointment

  • Q1.What are my specific cholesterol and triglyceride levels, and what are my target goals?,Do I need genetic testing to find out if my condition is inherited, and should my family members be tested?,Which medication is right for me, and what side effects should I watch for?,How much does diet and exercise alone help, and when is medication necessary?,How often do I need blood tests to monitor my lipid levels?,What is my overall risk of heart attack or stroke, and what can I do to lower it?,Are there any foods, supplements, or other medications I should avoid because they could worsen my lipid levels?

Common questions about OBSOLETE: Combined hyperlipidemia

What is OBSOLETE: Combined hyperlipidemia?

Combined hyperlipidemia, also known as familial combined hyperlipidemia (FCH or FCHL) or mixed hyperlipidemia, is a condition where the blood contains too much of more than one type of fat (lipid). Specifically, people with this condition have high levels of cholesterol, triglycerides, or both circulating in their bloodstream. The term 'combined' refers to this mix of elevated fats. It is worth noting that this Orphanet entry is marked as 'obsolete,' meaning it has been reorganized into more specific diagnostic categories in current medical classification systems. This condition affects the w

How is OBSOLETE: Combined hyperlipidemia inherited?

OBSOLETE: Combined hyperlipidemia follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does OBSOLETE: Combined hyperlipidemia typically begin?

Typical onset of OBSOLETE: Combined hyperlipidemia is adult. Age of onset can vary across affected individuals.