Overview
Chronic muscular fatigue and/or chronic muscle pain is a term that has been used to describe a condition where a person experiences ongoing tiredness in their muscles and/or persistent muscle pain that does not go away with normal rest. It is important to note that this diagnosis code has been marked as 'OBSOLETE' in the Orphanet classification system, meaning it is no longer considered a distinct, standalone rare disease category. Instead, patients who were previously classified under this term may now fall under more specific diagnoses such as fibromyalgia, chronic fatigue syndrome (also called myalgic encephalomyelitis), various myopathies, or other neuromuscular or rheumatological conditions. The main symptoms include muscles that feel tired or weak even without heavy physical activity, widespread or localized muscle pain, difficulty performing everyday tasks due to muscle discomfort, and a general sense of physical exhaustion. Some people also experience sleep problems, difficulty concentrating, and mood changes related to their ongoing pain and fatigue. Because this is an obsolete classification, patients who have been given this label should work with their doctors to determine a more specific and up-to-date diagnosis. Treatment depends entirely on the underlying cause and may include physical therapy, pain management, medications, lifestyle changes, and psychological support. Getting the right diagnosis is the most important step toward finding effective treatment.
Key symptoms:
Ongoing muscle tirednessChronic muscle painMuscle weaknessDifficulty with physical activitiesFatigue that does not improve with restSleep problemsDifficulty concentrating or brain fogStiffness in musclesReduced exercise toleranceMood changes such as anxiety or depression
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Chronic muscular fatigue and/or chronic muscle pain.
View clinical trials →Clinical Trials
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Chronic muscular fatigue and/or chronic muscle pain.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Chronic muscular fatigue and/or chronic muscle pain.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Has a specific underlying cause for my muscle fatigue and pain been identified?,What tests should I have to rule out treatable conditions like thyroid problems or vitamin deficiencies?,Should I be referred to a neurologist or rheumatologist for further evaluation?,What type of physical therapy or exercise program would be safe and helpful for me?,Are there medications that could help manage my symptoms with minimal side effects?,Could my symptoms be related to a genetic or inherited muscle condition?,What lifestyle changes can I make to improve my energy levels and reduce pain?
Common questions about OBSOLETE: Chronic muscular fatigue and/or chronic muscle pain
What is OBSOLETE: Chronic muscular fatigue and/or chronic muscle pain?
Chronic muscular fatigue and/or chronic muscle pain is a term that has been used to describe a condition where a person experiences ongoing tiredness in their muscles and/or persistent muscle pain that does not go away with normal rest. It is important to note that this diagnosis code has been marked as 'OBSOLETE' in the Orphanet classification system, meaning it is no longer considered a distinct, standalone rare disease category. Instead, patients who were previously classified under this term may now fall under more specific diagnoses such as fibromyalgia, chronic fatigue syndrome (also cal