Overview
Cerebrorenodigital syndrome is an extremely rare condition that was historically described as affecting the brain (cerebro), kidneys (reno), and fingers or toes (digital). This syndrome has been classified as 'OBSOLETE' in medical databases, meaning it is no longer recognized as a distinct, separate condition. This may be because the original cases were later reclassified under a different diagnosis, or because advances in genetic testing revealed that the features originally grouped together actually belong to another known syndrome. The condition was originally reported in a very small number of patients who showed a combination of brain abnormalities (which could include intellectual disability or structural brain differences), kidney malformations, and abnormalities of the fingers or toes. Because so few cases were ever described, detailed information about the full range of symptoms, the underlying genetic cause, and the best treatment approaches remains very limited. If you or a family member has been given this diagnosis, it is important to work with a clinical geneticist who can review the original findings and determine whether a more current diagnosis applies. Modern genetic testing tools, such as whole exome or whole genome sequencing, may help identify the precise genetic cause and guide appropriate management.
Key symptoms:
Brain abnormalities or differences in brain structureIntellectual disability or developmental delayKidney malformations or problems with kidney developmentAbnormalities of the fingers or toesExtra fingers or toes (polydactyly) or fused fingers or toesPossible growth problemsPossible seizures
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Cerebrorenodigital syndrome.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: Cerebrorenodigital syndrome at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Cerebrorenodigital syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Cerebrorenodigital syndrome.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Cerebrorenodigital syndrome.
Start the conversation →Latest news about OBSOLETE: Cerebrorenodigital syndrome
No recent news articles for OBSOLETE: Cerebrorenodigital syndrome.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is this diagnosis still considered valid, or should we pursue updated genetic testing to find a more current diagnosis?,What type of genetic testing would you recommend for our family?,How severe is the kidney involvement, and what monitoring is needed?,What developmental therapies should we start, and how soon?,Are there any clinical trials or research studies that might be relevant?,What is the chance that future children could be affected?,Can you refer us to a clinical geneticist who specializes in rare multi-system conditions?
Common questions about OBSOLETE: Cerebrorenodigital syndrome
What is OBSOLETE: Cerebrorenodigital syndrome?
Cerebrorenodigital syndrome is an extremely rare condition that was historically described as affecting the brain (cerebro), kidneys (reno), and fingers or toes (digital). This syndrome has been classified as 'OBSOLETE' in medical databases, meaning it is no longer recognized as a distinct, separate condition. This may be because the original cases were later reclassified under a different diagnosis, or because advances in genetic testing revealed that the features originally grouped together actually belong to another known syndrome. The condition was originally reported in a very small numb
At what age does OBSOLETE: Cerebrorenodigital syndrome typically begin?
Typical onset of OBSOLETE: Cerebrorenodigital syndrome is neonatal. Age of onset can vary across affected individuals.