Overview
Cerebrofacial arteriovenous metameric syndrome type 3 (CAMS 3) is an extremely rare vascular condition that involves abnormal connections between arteries and veins (called arteriovenous malformations or AVMs) in specific areas of the face and brain. The term 'metameric' refers to the idea that these malformations follow a developmental pattern related to segments of the embryo during early growth. In CAMS 3, the arteriovenous malformations typically affect the lower face, jaw area, and parts of the brain that develop from the same embryonic segment. Please note that this condition has been classified as 'OBSOLETE' in the Orphanet database, meaning the classification may have been merged into a broader category or reclassified under a different name, such as cerebrofacial arteriovenous metameric syndrome (CAMS) more generally, or Bonnet-Dechaume-Blanc syndrome depending on the specific features. Symptoms can vary widely but often include visible vascular malformations on the face, bleeding episodes, headaches, and neurological problems depending on the location and size of the brain AVMs. These malformations are typically present from birth, though they may not become apparent until later. Treatment is mainly focused on managing symptoms and may include procedures such as embolization (blocking abnormal blood vessels), surgery, or stereotactic radiosurgery. Because this is such a rare and complex condition, care usually requires a team of specialists working together.
Also known as:
Key symptoms:
Abnormal blood vessel formations on the faceAbnormal blood vessel formations in the brainFacial swelling or visible vascular marksHeadachesSeizuresNosebleeds or bleeding from facial lesionsVision problemsJaw or dental abnormalitiesNeurological deficits such as weakness on one side of the bodyPulsating sensation or bruit (audible blood flow) near affected areasPain in the face or headDifficulty with speech or swallowing if lower face is involved
Sporadic
Usually appears on its own, not inherited from a parent
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the exact location and extent of the arteriovenous malformations in my case?,What is the risk of bleeding or rupture from the brain AVMs?,What treatment options are recommended, and what are the risks and benefits of each?,How often should imaging follow-up be done?,Are there any activities or medications I should avoid?,Should I be referred to a specialized vascular malformation center?,What emergency signs should I watch for, and what should I do if they occur?
Common questions about OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3
What is OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3?
Cerebrofacial arteriovenous metameric syndrome type 3 (CAMS 3) is an extremely rare vascular condition that involves abnormal connections between arteries and veins (called arteriovenous malformations or AVMs) in specific areas of the face and brain. The term 'metameric' refers to the idea that these malformations follow a developmental pattern related to segments of the embryo during early growth. In CAMS 3, the arteriovenous malformations typically affect the lower face, jaw area, and parts of the brain that develop from the same embryonic segment. Please note that this condition has been cl
How is OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3 inherited?
OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3 follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3 typically begin?
Typical onset of OBSOLETE: Cerebrofacial arteriovenous metameric syndrome type 3 is neonatal. Age of onset can vary across affected individuals.