Overview
Autosomal dominant trichoodontoonychodysplasia with syndactyly is an extremely rare inherited condition that affects multiple parts of the body, particularly the hair (tricho-), teeth (odonto-), nails (onycho-), and fingers or toes (syndactyly means webbing or fusion of digits). The name of this condition describes its main features: abnormal hair growth or texture, dental problems such as missing or malformed teeth, nail abnormalities like thin or poorly formed nails, and fused or webbed fingers or toes. This condition is classified as 'obsolete' in the Orphanet database, which means it may have been reclassified, merged with another condition, or its original description may have been updated as medical knowledge advanced. Because this is an extremely rare condition with very limited published cases, much of what is known comes from a small number of affected families. The condition is present from birth, and its features are typically noticed in early childhood. Treatment is mainly supportive and focuses on managing individual symptoms — for example, dental care for tooth abnormalities, surgical options for syndactyly, and dermatological care for hair and nail problems. There is no known cure, and management involves a team of specialists working together to address each affected body system.
Also known as:
Key symptoms:
Abnormal or sparse hairThin or brittle nailsMissing or malformed teethWebbed or fused fingers or toesDry or rough skinSlow-growing hairSmall or oddly shaped nailsDelayed eruption of teethFine or wispy hair textureAbnormal tooth enamel
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly.
Start the conversation →Latest news about OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly
No recent news articles for OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is genetic testing available to confirm the diagnosis in our family?,When is the best time to consider surgery for webbed fingers or toes?,What dental treatments are recommended and when should they start?,Are there other family members who should be evaluated?,What specialists should be part of our care team?,Are there any clinical trials or research studies we could participate in?,How can we best support our child's self-esteem given the visible features of this condition?
Common questions about OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly
What is OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly?
Autosomal dominant trichoodontoonychodysplasia with syndactyly is an extremely rare inherited condition that affects multiple parts of the body, particularly the hair (tricho-), teeth (odonto-), nails (onycho-), and fingers or toes (syndactyly means webbing or fusion of digits). The name of this condition describes its main features: abnormal hair growth or texture, dental problems such as missing or malformed teeth, nail abnormalities like thin or poorly formed nails, and fused or webbed fingers or toes. This condition is classified as 'obsolete' in the Orphanet database, which means it may h
How is OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly inherited?
OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly typically begin?
Typical onset of OBSOLETE: Autosomal dominant trichoodontoonychodysplasia-syndactyly is neonatal. Age of onset can vary across affected individuals.