Overview
Aseptic osteitis is an outdated or obsolete medical term that was previously used to describe inflammation of bone tissue that occurs without a bacterial or infectious cause. The word 'aseptic' means 'without infection,' and 'osteitis' means 'inflammation of bone.' This condition has been reclassified and is now better understood under more specific diagnoses, such as chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO), depending on the pattern and location of bone involvement. In conditions that fall under this umbrella, the immune system mistakenly attacks bone tissue, causing pain, swelling, and tenderness — usually without any sign of bacterial infection. The bones most commonly affected include those in the legs, collarbone, spine, and chest wall. Symptoms can come and go over time, which can make diagnosis challenging. Because this term is now considered obsolete in modern medicine, patients who have received this label in the past are encouraged to speak with a specialist to get an updated diagnosis. Treatment today focuses on reducing inflammation and managing pain, often using anti-inflammatory medications. Understanding the correct, current diagnosis is important for getting the best possible care.
Key symptoms:
Bone pain, often in the legs, collarbone, or spineSwelling or tenderness over affected bonesWarmth or redness over the painful areaFatigue or general tirednessFever (usually low-grade or absent)Difficulty walking or moving the affected limbSymptoms that come and go over weeks or months
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Aseptic osteitis.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Aseptic osteitis.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Aseptic osteitis.
Community
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Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is 'aseptic osteitis' still the right diagnosis for me, or should I be evaluated for a more specific condition like CRMO or CNO?,What tests do I need to confirm the diagnosis and rule out infection or other causes?,What are my treatment options, and what are the risks and benefits of each?,How will we know if the treatment is working?,Are there any long-term complications I should watch for?,Should I see a specialist in rheumatology or bone disorders?,Is there a genetic component to my condition that could affect other family members?
Common questions about OBSOLETE: Aseptic osteitis
What is OBSOLETE: Aseptic osteitis?
Aseptic osteitis is an outdated or obsolete medical term that was previously used to describe inflammation of bone tissue that occurs without a bacterial or infectious cause. The word 'aseptic' means 'without infection,' and 'osteitis' means 'inflammation of bone.' This condition has been reclassified and is now better understood under more specific diagnoses, such as chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO), depending on the pattern and location of bone involvement. In conditions that fall under this umbrella, the immune system mistakenly