Overview
Anomaly of chromosome 15 is a broad term that was previously used to describe a group of genetic conditions caused by changes in chromosome 15. This term is now considered obsolete in medical classification systems, meaning it has been replaced by more specific diagnoses. Chromosome 15 abnormalities can include missing pieces (deletions), extra pieces (duplications), rearrangements, or having an extra copy of part or all of chromosome 15. These changes can lead to a wide range of health problems depending on exactly which part of chromosome 15 is affected and how much genetic material is involved. Well-known conditions linked to chromosome 15 changes include Prader-Willi syndrome, Angelman syndrome, and chromosome 15q duplication syndrome (Dup15q). Symptoms can vary greatly but may include intellectual disability, developmental delays, unusual facial features, growth problems, seizures, and behavioral differences. Some people may have mild symptoms while others are more severely affected. Because this is an umbrella term rather than a single specific condition, treatment depends entirely on the exact chromosome 15 change identified and the symptoms present. Management is typically supportive and tailored to each person's needs, involving a team of specialists. If you or your child has been given this diagnosis, it is important to get a more specific genetic diagnosis so that the right care plan can be developed.
Key symptoms:
Intellectual disabilityDevelopmental delaysSpeech and language delaysSeizures or epilepsyLow muscle tone (floppiness)Growth problems (too short or too tall)Unusual facial featuresFeeding difficulties in infancyBehavioral challengesLearning difficultiesObesity or unusual weight gainSleep problemsCoordination difficultiesAnxiety or mood changes
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Anomaly of chromosome 15.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Anomaly of chromosome 15.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Anomaly of chromosome 15.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific type of chromosome 15 change does my child have, and what does it mean?,What symptoms should I watch for as my child grows?,What therapies and early interventions should we start right away?,Are there any clinical trials or new treatments being studied for this condition?,How often should we have follow-up appointments and with which specialists?,Is there a risk that other family members could have the same chromosome change?,What resources and support groups are available for families affected by this condition?
Common questions about OBSOLETE: Anomaly of chromosome 15
What is OBSOLETE: Anomaly of chromosome 15?
Anomaly of chromosome 15 is a broad term that was previously used to describe a group of genetic conditions caused by changes in chromosome 15. This term is now considered obsolete in medical classification systems, meaning it has been replaced by more specific diagnoses. Chromosome 15 abnormalities can include missing pieces (deletions), extra pieces (duplications), rearrangements, or having an extra copy of part or all of chromosome 15. These changes can lead to a wide range of health problems depending on exactly which part of chromosome 15 is affected and how much genetic material is invol