Nasolacrimal duct cyst

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Overview

A nasolacrimal duct cyst, also known as a dacryocystocele or lacrimal sac mucocele, is a congenital or acquired cystic dilation of the nasolacrimal duct system. This condition affects the lacrimal drainage apparatus, which is the system responsible for draining tears from the eye into the nasal cavity. The cyst forms when both the upper (valve of Rosenmuller) and lower (valve of Hasner) ends of the nasolacrimal duct become obstructed, trapping fluid within the duct or lacrimal sac and causing it to expand into a fluid-filled cyst. In congenital cases, the cyst typically presents at birth or shortly thereafter as a bluish, tense swelling at the inner corner of the eye (medial canthus), below or adjacent to the medial canthal tendon. It may also extend intranasally, presenting as an intranasal mass. Key symptoms include a visible swelling near the inner corner of the eye, epiphora (excessive tearing), and potential respiratory distress in neonates if the intranasal component is large enough to cause nasal obstruction — particularly significant because neonates are obligate nasal breathers. Secondary infection of the cyst (dacryocystitis) can occur, presenting with redness, warmth, tenderness, and purulent discharge. In some cases, the cyst may resolve spontaneously. However, when intervention is required, treatment options include conservative management with warm compresses and gentle massage (Crigler massage), nasolacrimal duct probing, marsupialization of the intranasal component, or in more complex cases, endoscopic surgical excision. Topical or systemic antibiotics may be used if secondary infection develops. Early recognition and management are important to prevent complications such as recurrent infections, amblyopia from obstruction of the visual axis, or respiratory compromise in newborns.

Also known as:

Clinical phenotype terms— hover any for plain English:

Nasolacrimal duct obstructionHP:0000579DacryocystitisHP:0000620Nasal congestionHP:0001742Paroxysmal dyspneaHP:0012763Inappropriate cryingHP:0030215Abnormal breath soundHP:0030829Abnormal lacrimal sac morphologyHP:3000066Deviated nasal septumHP:0004411Episodic respiratory distressHP:0004885Ectropion of lower eyelidsHP:0007651Chronic irritative conjunctivitisHP:0007717Red eyeHP:0025337Corneal astigmatismHP:0025612DacryocystoceleHP:0030752
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Nasolacrimal duct cyst.

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No actively recruiting trials found for Nasolacrimal duct cyst at this time.

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Specialists

1 foundView all specialists →
MM
Mohamed F Ibrahiem, MD
Specialist
PI on 2 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

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Common questions about Nasolacrimal duct cyst

What is Nasolacrimal duct cyst?

A nasolacrimal duct cyst, also known as a dacryocystocele or lacrimal sac mucocele, is a congenital or acquired cystic dilation of the nasolacrimal duct system. This condition affects the lacrimal drainage apparatus, which is the system responsible for draining tears from the eye into the nasal cavity. The cyst forms when both the upper (valve of Rosenmuller) and lower (valve of Hasner) ends of the nasolacrimal duct become obstructed, trapping fluid within the duct or lacrimal sac and causing it to expand into a fluid-filled cyst. In congenital cases, the cyst typically presents at birth or sh

How is Nasolacrimal duct cyst inherited?

Nasolacrimal duct cyst follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Nasolacrimal duct cyst typically begin?

Typical onset of Nasolacrimal duct cyst is neonatal. Age of onset can vary across affected individuals.

Which specialists treat Nasolacrimal duct cyst?

1 specialists and care centers treating Nasolacrimal duct cyst are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.