Overview
A nasolacrimal duct cyst, also known as a dacryocystocele or lacrimal sac mucocele, is a congenital or acquired cystic dilation of the nasolacrimal duct system. This condition affects the lacrimal drainage apparatus, which is the system responsible for draining tears from the eye into the nasal cavity. The cyst forms when both the upper (valve of Rosenmuller) and lower (valve of Hasner) ends of the nasolacrimal duct become obstructed, trapping fluid within the duct or lacrimal sac and causing it to expand into a fluid-filled cyst. In congenital cases, the cyst typically presents at birth or shortly thereafter as a bluish, tense swelling at the inner corner of the eye (medial canthus), below or adjacent to the medial canthal tendon. It may also extend intranasally, presenting as an intranasal mass. Key symptoms include a visible swelling near the inner corner of the eye, epiphora (excessive tearing), and potential respiratory distress in neonates if the intranasal component is large enough to cause nasal obstruction — particularly significant because neonates are obligate nasal breathers. Secondary infection of the cyst (dacryocystitis) can occur, presenting with redness, warmth, tenderness, and purulent discharge. In some cases, the cyst may resolve spontaneously. However, when intervention is required, treatment options include conservative management with warm compresses and gentle massage (Crigler massage), nasolacrimal duct probing, marsupialization of the intranasal component, or in more complex cases, endoscopic surgical excision. Topical or systemic antibiotics may be used if secondary infection develops. Early recognition and management are important to prevent complications such as recurrent infections, amblyopia from obstruction of the visual axis, or respiratory compromise in newborns.
Also known as:
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Sporadic
Usually appears on its own, not inherited from a parent
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Nasolacrimal duct cyst.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
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Common questions about Nasolacrimal duct cyst
What is Nasolacrimal duct cyst?
A nasolacrimal duct cyst, also known as a dacryocystocele or lacrimal sac mucocele, is a congenital or acquired cystic dilation of the nasolacrimal duct system. This condition affects the lacrimal drainage apparatus, which is the system responsible for draining tears from the eye into the nasal cavity. The cyst forms when both the upper (valve of Rosenmuller) and lower (valve of Hasner) ends of the nasolacrimal duct become obstructed, trapping fluid within the duct or lacrimal sac and causing it to expand into a fluid-filled cyst. In congenital cases, the cyst typically presents at birth or sh
How is Nasolacrimal duct cyst inherited?
Nasolacrimal duct cyst follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Nasolacrimal duct cyst typically begin?
Typical onset of Nasolacrimal duct cyst is neonatal. Age of onset can vary across affected individuals.
Which specialists treat Nasolacrimal duct cyst?
1 specialists and care centers treating Nasolacrimal duct cyst are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.