Overview
Malignant lymphoma with peripheral neuropathy is a rare condition in which a type of blood cancer called lymphoma occurs together with damage to the peripheral nerves (the nerves outside the brain and spinal cord). Lymphoma is a cancer that starts in white blood cells called lymphocytes, which are part of the immune system. In this condition, the lymphoma either directly damages the peripheral nerves or triggers the immune system to attack them. This nerve damage is called peripheral neuropathy and can cause numbness, tingling, pain, or weakness in the hands and feet. The peripheral neuropathy may appear before, during, or after the lymphoma is diagnosed. Sometimes the nerve symptoms are the first clue that a lymphoma is present. The neuropathy can result from the tumor pressing on or invading nerves, from substances produced by the cancer cells, or from the body's immune response mistakenly attacking its own nerve tissue (a paraneoplastic process). In some cases, certain lymphoma treatments such as chemotherapy can also contribute to nerve damage. Treatment focuses on addressing both the underlying lymphoma and the nerve symptoms. Lymphoma treatment may include chemotherapy, immunotherapy, radiation therapy, or stem cell transplant depending on the type and stage. Managing the neuropathy often involves pain medications, physical therapy, and supportive care. Early diagnosis and treatment of the lymphoma can sometimes improve or stabilize the neuropathy, though nerve damage may not always be fully reversible.
Key symptoms:
Numbness or tingling in hands and feetBurning or shooting pain in the limbsMuscle weakness in arms or legsDifficulty walking or balance problemsSwollen lymph nodesUnexplained weight lossNight sweatsPersistent fatigueFever without infectionLoss of sensation in fingers or toesDifficulty gripping objectsMuscle wastingLoss of reflexes
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
10 eventsThe Hong Kong Polytechnic University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Malignant lymphoma with peripheral neuropathy.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Malignant lymphoma with peripheral neuropathy at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesTAFINLAR
Novartis Pharmaceuticals Corp.
TAFINLAR Patient Support (Novartis Patient Assistance)
Travel Grants
No travel grants are currently matched to Malignant lymphoma with peripheral neuropathy.
Community
No community posts yet. Be the first to share your experience with Malignant lymphoma with peripheral neuropathy.
Start the conversation →Latest news about Malignant lymphoma with peripheral neuropathy
Disease timeline:
New recruiting trial: Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia
A new clinical trial is recruiting patients for Malignant lymphoma with peripheral neuropathy
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What type and stage of lymphoma do I have, and how does it relate to my nerve symptoms?,Is my peripheral neuropathy caused directly by the lymphoma, by my immune system, or by treatment?,Which chemotherapy drugs are safest for me given my neuropathy, and can any be avoided?,What treatments are available to manage my nerve pain and weakness?,Is the nerve damage likely to improve with lymphoma treatment, or could it be permanent?,Should I see a neurologist in addition to my oncologist?,What rehabilitation services or physical therapy would help me maintain function?
Common questions about Malignant lymphoma with peripheral neuropathy
What is Malignant lymphoma with peripheral neuropathy?
Malignant lymphoma with peripheral neuropathy is a rare condition in which a type of blood cancer called lymphoma occurs together with damage to the peripheral nerves (the nerves outside the brain and spinal cord). Lymphoma is a cancer that starts in white blood cells called lymphocytes, which are part of the immune system. In this condition, the lymphoma either directly damages the peripheral nerves or triggers the immune system to attack them. This nerve damage is called peripheral neuropathy and can cause numbness, tingling, pain, or weakness in the hands and feet. The peripheral neuropath
How is Malignant lymphoma with peripheral neuropathy inherited?
Malignant lymphoma with peripheral neuropathy follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Malignant lymphoma with peripheral neuropathy typically begin?
Typical onset of Malignant lymphoma with peripheral neuropathy is adult. Age of onset can vary across affected individuals.
Which specialists treat Malignant lymphoma with peripheral neuropathy?
8 specialists and care centers treating Malignant lymphoma with peripheral neuropathy are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Malignant lymphoma with peripheral neuropathy?
1 patient support program are currently tracked on UniteRare for Malignant lymphoma with peripheral neuropathy. See the treatments and support programs sections for copay assistance, eligibility, and contact details.