Overview
Lymphoplasmacytic lymphoma without IgM production is a rare type of blood cancer that affects certain white blood cells called B-cells. Normally, B-cells help fight infections by making antibodies. In this disease, abnormal B-cells and plasma cells (a more mature type of B-cell) grow out of control in the bone marrow, lymph nodes, and spleen. Unlike the more common form of this cancer — called Waldenström's macroglobulinemia — this version does not produce large amounts of a specific antibody protein called IgM. This makes it harder to detect and sometimes harder to diagnose. Because the abnormal cells crowd out healthy blood cells in the bone marrow, people with this condition often feel very tired, get infections more easily, and may bleed or bruise more than usual. Swollen lymph nodes, an enlarged spleen, and unexplained weight loss are also common. Some people have no symptoms at first and are only found to have the disease during routine blood tests. Treatment depends on how severe the disease is and whether it is causing symptoms. Some people with mild disease are monitored closely without immediate treatment — a strategy called 'watch and wait.' When treatment is needed, doctors may use chemotherapy, targeted drugs, or a combination of both. While this disease is not usually curable, many people live for years with good quality of life when managed carefully by a specialist team.
Key symptoms:
Extreme tiredness and low energySwollen lymph nodes in the neck, armpits, or groinEnlarged spleen causing discomfort or fullness in the bellyFrequent infections due to a weakened immune systemUnexplained weight lossNight sweatsFever without a clear causeEasy bruising or unusual bleedingPale skin from low red blood cell counts (anemia)Shortness of breath with mild activity
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for Lymphoplasmacytic lymphoma without IgM production.
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Specialists
View all specialists →No specialists are currently listed for Lymphoplasmacytic lymphoma without IgM production.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Lymphoplasmacytic lymphoma without IgM production.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is my disease currently active, or can we use a watch-and-wait approach?,Which treatment do you recommend for me, and why?,Should I be tested for the MYD88 mutation, and how does that affect my treatment options?,Are there any clinical trials I might be eligible for?,How often will I need blood tests and check-ups?,What signs or symptoms should prompt me to call you or go to the emergency room?,How will treatment affect my daily life and ability to work?
Common questions about Lymphoplasmacytic lymphoma without IgM production
What is Lymphoplasmacytic lymphoma without IgM production?
Lymphoplasmacytic lymphoma without IgM production is a rare type of blood cancer that affects certain white blood cells called B-cells. Normally, B-cells help fight infections by making antibodies. In this disease, abnormal B-cells and plasma cells (a more mature type of B-cell) grow out of control in the bone marrow, lymph nodes, and spleen. Unlike the more common form of this cancer — called Waldenström's macroglobulinemia — this version does not produce large amounts of a specific antibody protein called IgM. This makes it harder to detect and sometimes harder to diagnose. Because the abno
How is Lymphoplasmacytic lymphoma without IgM production inherited?
Lymphoplasmacytic lymphoma without IgM production follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Lymphoplasmacytic lymphoma without IgM production typically begin?
Typical onset of Lymphoplasmacytic lymphoma without IgM production is adult. Age of onset can vary across affected individuals.