Lyme disease

Last reviewed March 21, 2026

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ORPHA:91546A69.2

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20Active trials 57Specialists 8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

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Overview

Also known as:

Lyme borreliosis

Clinical phenotype terms— hover any for plain English:

Atrioventricular blockHP:0001678Infectious encephalitisHP:0002383

Orphanet ↗NORD ↗

FDA & Trial Timeline

10 events

Apr 2026A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

Pfizer — PHASE3

TrialNOT YET RECRUITING

Mar 2026Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.

Radboud University Medical Center — PHASE4

TrialNOT YET RECRUITING

Feb 2026Ceftriaxone for Post-Treatment Lyme Disease

Hackensack Meridian Health — PHASE1, PHASE2

TrialRECRUITING

Jan 2026Borrelia Arthritis - a Hidden Cause of Arthritis in Danish Patients?

Fredrikke Christie Knudtzen

TrialNOT YET RECRUITING

Nov 2025A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults

Pfizer — PHASE3

TrialRECRUITING

Aug 2025A Multicenter Real-life Study of Disseminated Borreliosis Cases Occurring in Patients Receiving Anti-CD20 Treatment in France

University Hospital, Strasbourg, France

TrialRECRUITING

Jul 2025Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))

Biocodex — PHASE4

TrialRECRUITING

Jul 2025Transcranial Direct Current Stimulation for Post Treatment Lyme Disease

Columbia University — NA

TrialRECRUITING

May 2025Anti-phospolipid Antibodies in Lyme Borreliosis

University Medical Centre Ljubljana

TrialNOT YET RECRUITING

Feb 2025Study of the Clinical, Microbiological and Epidemiological Characteristics of Recurrent Imported Borreliosis Confirmed by the CNR Borrelia

University Hospital, Strasbourg, France

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Lyme disease.

20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

20 recruitingView all trials with filters →

Phase 32 trials

A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults

Phase 3

Actively Recruiting

PI: Pfizer CT.gov Call Center (Pfizer) · Sites: Pittsburgh, Pennsylvania; Pittsburgh, Pennsylvania +3 more · Age: 18–44 yrs

An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15)

Phase 3

Active

PI: Pfizer CT.gov Call Center (Pfizer) · Sites: Essex, Connecticut; New London, Connecticut +118 more · Age: 5–99 yrs

Phase 41 trial

Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))

Phase 4

Actively Recruiting

PI: Oana BERNARD, MD (Chief Scientific Officer) · Sites: Ljubljana · Age: 18–99 yrs

Phase 21 trial

Tetracycline Treatment Tolerability Trial

Phase 2

Enrolling by Invitation

PI: John N. Aucott, MD (Johns Hopkins University) · Sites: Lutherville, Maryland · Age: 18–80 yrs

N/A4 trials

Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain

N/A

Actively Recruiting

PI: David Putrino, PT, PhD (Icahn School of Medicine at Mount Sinai) · Sites: New York, New York · Age: 18–99 yrs

taVNS for Persistent Symptoms From Lyme Disease

N/A

Actively Recruiting

PI: Brian A. Fallon, MD (Columbia University) · Sites: New York, New York · Age: 18–65 yrs

Transcranial Direct Current Stimulation for Post Treatment Lyme Disease

N/A

Actively Recruiting

PI: Brian A Fallon, MD (Columbia University) · Sites: San Francisco, California; New York, New York · Age: 18–65 yrs

Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.

N/A

Actively Recruiting

PI: David HUPIN, MD (CHU de Saint Etienne) · Sites: Clermont-Ferrand; Saint-Etienne · Age: 18–99 yrs

Other8 trials

Navigating Pregnancy and Parenthood With Lyme Disease

Actively Recruiting

PI: Sarah B. Mulkey, MD, PhD (Children's National Research Institute) · Sites: Washington D.C., District of Columbia · Age: 18–99 yrs

Clinicaly Manifested Reinfections with Borrelia Burgdorferi Sensu Lato

Active

· Sites: Ljubljana · Age: 18–99 yrs

A Prospective Study to Evaluate the Role of T-Cell Dysfunction in Patients Who Present Symptoms Associated With Long COVID, Lyme Disease and Myalic Encephalomyelitis / Chronic Fatigue Syndrome Using the Vira Immune Fluorospot T Cell Assay

Active

· Sites: Airdrie; Glasgow +1 more · Age: 15–99 yrs

Evaluation, Treatment, and Follow-up of Patients With Lyme Disease

Actively Recruiting

PI: Adriana R Marques, M.D. (National Institute of Allergy and Infectious Disea) · Sites: Bethesda, Maryland · Age: 2–99 yrs

A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

Actively Recruiting

PI: Adriana R Marques, M.D. (National Institute of Allergy and Infectious Disea) · Sites: Bethesda, Maryland · Age: 13–99 yrs

Borrelia B-cell Diagnostics

Actively Recruiting

PI: Patrick M Meyer Sauteur, MD PhD (Division of infectious diseases Univesity Children) · Sites: Zurich · Age: 0–17 yrs

Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure

Actively Recruiting

PI: Sarah Mulkey, MD, PhD (Children's National Research Institute) · Sites: Washington D.C., District of Columbia · Age: 18–99 yrs

Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in Alsace

Actively Recruiting

· Sites: Strasbourg, Les Hôpitaux Universitaires de Strasbourg · Age: 18–99 yrs

Specialists

Showing 25 of 57View all specialists →

BM

Brian A Fallon, MD

Specialist

PI on 4 active trials

Active trials Directions Travel grants

MM

Matthew H. Liang, MD, MPH

BOSTON, MA

Specialist

PI on 1 active trial

Active trials Directions Travel grants

CM

Christoph Berger, MD

Specialist

PI on 1 active trial

Active trials Directions Travel grants

AM

Adriana R Marques, M.D.

BETHESDA, MD

Specialist

PI on 8 active trials

Active trials Directions Travel grants

PP

Patrick M Meyer Sauteur, MD PhD

Specialist

PI on 1 active trial

Active trials Directions Travel grants

MP

Morten Lindbak, Professor

Specialist

PI on 1 active trial1 Lyme disease publication

Active trials Directions Travel grants

BM

Bart-Jan Kullberg, Prof., M.D.

Specialist

PI on 1 active trial

Active trials Directions Travel grants

DP

David Pitrak

BURR RIDGE, IL

Specialist

2 Lyme disease publications

Directions Travel grants

ES

Eugene D Shapiro

Specialist

2 Lyme disease publications

Directions Travel grants

ME

Monica E Embers

Specialist

2 Lyme disease publications

Directions Travel grants

AC

Adam S Cifu

CHICAGO, IL

Specialist

2 Lyme disease publications

Directions Travel grants

CN

Cynthia T Nguyen

Specialist

2 Lyme disease publications

Directions Travel grants

RS

Robert P Smith

Specialist

1 Lyme disease publication

Directions Travel grants

TK

Takaaki Kobayashi

LEXINGTON, KY

Specialist

2 Lyme disease publications

Directions Travel grants

BF

Brian A Fallon

Specialist

2 Lyme disease publications

Directions Travel grants

PA

Paul G Auwaerter

LUTHERVILLE, MD

Specialist

2 Lyme disease publications

Directions Travel grants

CM

Carol A McCarthy

Specialist

2 Lyme disease publications

Directions Travel grants

JH

John J Halperin

SUMMIT, NJ

Specialist

2 Lyme disease publications

Directions Travel grants

VM

Vikram K Mahajan

TAMPA, FL

Specialist

1 Lyme disease publication

Directions Travel grants

GW

Gary P Wormser

HAWTHORNE, NY

Specialist

2 Lyme disease publications

Directions Travel grants

DP

Daša Stupica, MD PhD

Specialist

PI on 5 active trials

Active trials Directions Travel grants

NM

Namita Singh, MD

WEST VALLEY, UT

Specialist

PI on 1 active trial

Active trials Directions Travel grants

EM

Emma M Groarke, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

Aplastic Anemia Idiopathic aplastic anemia Rare aplastic anemia

PI on 5 active trials

Active trials Directions Travel grants

DP

David Putrino, PhD, PT

Specialist

ADULT syndrome Infectious disease of the nervous system

PI on 2 active trials

Active trials Directions Travel grants

KM

Kristopher Paolino, MD

PITTSBURGH, PA

Specialist

Hantavirus pulmonary syndrome Hemorrhagic fever-renal syndrome

PI on 2 active trials

Active trials Directions Travel grants

Treatment Centers

8 centers

⚗️ Trial Site

National Institutes of Health Clinical Center

📍 Bethesda, Maryland

👤 Payal P Khincha, M.D.

👤 Christopher Grunseich, M.D.

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Travel Grants

No travel grants are currently matched to Lyme disease.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Lyme diseaseForum →

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Latest news about Lyme disease

Disease timeline:

New recruiting trial: Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: taVNS for Persistent Symptoms From Lyme Disease

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: Borrelia B-cell Diagnostics

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: Ceftriaxone for Post-Treatment Lyme Disease

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: Study of the Clinical, Microbiological and Epidemiological Characteristics of Recurrent Imported Borreliosis Confirmed by the CNR Borrelia

A new clinical trial is recruiting patients for Lyme disease

New recruiting trial: 64Cu-DOTATATE-PET for Lyme Neuroborreliosis

A new clinical trial is recruiting patients for Lyme disease

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Lyme disease

Are there clinical trials for Lyme disease?

Yes — 20 recruiting clinical trials are currently listed for Lyme disease on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Lyme disease?

25 specialists and care centers treating Lyme disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.