Overview
Linear focal elastosis (LFE), also known as elastotic striae, is a rare benign dermatological condition characterized by the development of yellowish, palpable, horizontally oriented linear bands or striae, most commonly found on the lower back (lumbosacral region). The condition primarily affects the skin and is caused by an abnormal increase in elastic fibers within the dermis. Histopathologically, LFE shows a marked increase in fragmented and thickened elastic fibers in the mid and lower dermis, distinguishing it from other conditions such as striae distensae or elastoderma. Linear focal elastosis predominantly affects middle-aged to older adults and appears to have a predilection for males. The lesions are typically asymptomatic and are often discovered incidentally. They may resemble striae distensae (stretch marks) in appearance but differ in that they are raised or palpable rather than atrophic, and they show elastin accumulation rather than loss on biopsy. The condition is considered a localized form of connective tissue nevus or an acquired elastosis. There is currently no established curative treatment for linear focal elastosis. Because the condition is benign and asymptomatic, management is generally conservative, with reassurance being the primary approach. No systemic complications have been reported. The exact etiology remains unclear, though it is thought to represent a localized disorder of elastic tissue production or degradation. The condition is not known to be associated with systemic connective tissue disorders.
Also known as:
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for Linear focal elastosis.
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Specialists
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Linear focal elastosis.
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Common questions about Linear focal elastosis
What is Linear focal elastosis?
Linear focal elastosis (LFE), also known as elastotic striae, is a rare benign dermatological condition characterized by the development of yellowish, palpable, horizontally oriented linear bands or striae, most commonly found on the lower back (lumbosacral region). The condition primarily affects the skin and is caused by an abnormal increase in elastic fibers within the dermis. Histopathologically, LFE shows a marked increase in fragmented and thickened elastic fibers in the mid and lower dermis, distinguishing it from other conditions such as striae distensae or elastoderma. Linear focal e
How is Linear focal elastosis inherited?
Linear focal elastosis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Linear focal elastosis typically begin?
Typical onset of Linear focal elastosis is adult. Age of onset can vary across affected individuals.