Ledderhose disease

Ledderhose disease, also known as plantar fibromatosis or morbus Ledderhose, is a benign fibroproliferative disorder affecting the plantar fascia of the foot. It is characterized by the development of firm, nodular growths (fibromas) within the plantar aponeurosis — the thick band of connective tissue on the sole of the foot. These nodules typically develop gradually and may be single or multiple, unilateral or bilateral. The condition is considered part of the spectrum of superficial fibromatoses, which also includes Dupuytren disease (palmar fibromatosis) and Peyronie disease (penile fibromatosis). Indeed, Ledderhose disease frequently co-occurs with Dupuytren disease, and the two conditions share similar pathological features. Patients commonly present with firm, slow-growing nodules on the sole of the foot, most often in the medial arch area. In early stages, the nodules may be painless, but as they enlarge, they can cause significant discomfort during walking or standing, particularly when pressing against weight-bearing surfaces. In more advanced cases, the fibrotic tissue may contract, leading to toe contractures (curling of the toes), although this is less common than the contractures seen in Dupuytren disease of the hand. The condition predominantly affects middle-aged and older adults and is more common in males. Treatment of Ledderhose disease is primarily conservative in early or mild cases and may include cushioned insoles, orthotic devices, physical therapy, and corticosteroid injections to reduce pain and inflammation. Radiation therapy has been used in early-stage disease to slow nodule progression. For refractory or severe cases causing significant functional impairment, surgical excision — including subtotal or total fasciectomy — may be considered, although recurrence rates after surgery can be high. Collagenase injections and cryotherapy have also been explored as treatment options. There is currently no cure, and management focuses on symptom relief and maintaining mobility.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Common questions about Ledderhose disease