Jessner lymphocytic infiltration of the skin

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Overview

Jessner lymphocytic infiltration of the skin (also called Jessner's lymphocytic infiltrate or Jessner-Kanof disease) is a rare, benign skin condition where certain white blood cells called lymphocytes build up in the skin without any clear cause. Despite the word 'infiltration,' this is not a cancer — it is a harmless but often frustrating condition that tends to come and go over time. The condition mainly affects the skin on the face, neck, and upper back. It causes raised, reddish or pinkish bumps and patches that can look similar to other skin diseases, which sometimes makes it tricky to diagnose. The patches are usually not painful or itchy, though some people do notice mild discomfort or a burning feeling. Sun exposure can trigger or worsen flare-ups in many people. There is no cure for Jessner lymphocytic infiltration, but several treatments can help reduce the appearance of the skin lesions and manage flare-ups. These include sun protection, topical or injected corticosteroids, antimalarial drugs like hydroxychloroquine, and in some cases light-based therapies. The condition is generally not dangerous to overall health, but it can affect a person's confidence and quality of life because of its visible nature on the face and neck.

Also known as:

Key symptoms:

Raised, reddish or pink bumps on the skinSmooth, firm skin patches on the face, neck, or upper backSkin lesions that come and go over weeks or monthsWorsening of skin patches after sun exposureMild burning or discomfort in affected areasNo scarring when lesions healPatches that slowly grow outward over timeSkin lesions that do not itch in most cases

Clinical phenotype terms (6)— hover any for plain English
Abnormal lymphocyte morphologyHP:0004332
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Jessner lymphocytic infiltration of the skin.

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No actively recruiting trials found for Jessner lymphocytic infiltration of the skin at this time.

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No specialists are currently listed for Jessner lymphocytic infiltration of the skin.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Jessner lymphocytic infiltration of the skin.

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Community

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Questions for your doctor

Bring these to your next appointment

  • Q1.How certain are you that this is Jessner lymphocytic infiltration and not lupus or another condition?,What treatment do you recommend for my specific case, and how long before I might see results?,Are there any triggers besides sun exposure that I should try to avoid?,How often should I come in for follow-up appointments?,If my skin does not improve with the first treatment, what are the next options?,Should I see an eye doctor if I am prescribed hydroxychloroquine?,Is there anything about my lifestyle or diet that could help reduce flare-ups?

Common questions about Jessner lymphocytic infiltration of the skin

What is Jessner lymphocytic infiltration of the skin?

Jessner lymphocytic infiltration of the skin (also called Jessner's lymphocytic infiltrate or Jessner-Kanof disease) is a rare, benign skin condition where certain white blood cells called lymphocytes build up in the skin without any clear cause. Despite the word 'infiltration,' this is not a cancer — it is a harmless but often frustrating condition that tends to come and go over time. The condition mainly affects the skin on the face, neck, and upper back. It causes raised, reddish or pinkish bumps and patches that can look similar to other skin diseases, which sometimes makes it tricky to d

How is Jessner lymphocytic infiltration of the skin inherited?

Jessner lymphocytic infiltration of the skin follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Jessner lymphocytic infiltration of the skin typically begin?

Typical onset of Jessner lymphocytic infiltration of the skin is adult. Age of onset can vary across affected individuals.