Overview
Intellectual disability, Wolff type (also known as Wolff syndrome) is an extremely rare genetic condition that primarily affects brain development and intellectual function. It was first described in the medical literature and is characterized by intellectual disability along with certain physical features. People with this condition typically show delays in learning and development from early childhood. The condition falls under a group of disorders that combine intellectual disability with other body differences, which is why it is classified under the ICD-10 code Q87.0 (congenital malformation syndromes predominantly affecting facial appearance or other specified congenital malformation syndromes). Because this condition is so rare, detailed information about its full range of symptoms and natural history is limited. The hallmark feature is intellectual disability, which can range from mild to more significant. Some affected individuals may also have distinctive facial features or other physical findings. There is currently no cure for this condition. Treatment focuses on supportive care, including special education services, speech and occupational therapy, and other interventions aimed at helping individuals reach their fullest potential. Early intervention programs can make a meaningful difference in developmental outcomes.
Also known as:
Key symptoms:
Intellectual disabilityDelayed speech and language developmentLearning difficultiesDelayed motor milestones such as sitting and walkingPossible distinctive facial featuresDifficulty with daily living skillsBehavioral challengesPossible short stature
Clinical phenotype terms (29)— hover any for plain English
Variable
Can be inherited in different ways depending on the underlying gene
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for Intellectual disability, Wolff type.
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Specialists
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Intellectual disability, Wolff type.
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Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the expected range of intellectual disability in my child's case?,What therapies and early intervention services do you recommend?,Should we pursue genetic testing, and if so, what kind?,Are there any associated medical problems we should screen for?,How can we best support our child's development at home?,What educational resources and support services are available?,What should we plan for as our child transitions into adulthood?
Common questions about Intellectual disability, Wolff type
What is Intellectual disability, Wolff type?
Intellectual disability, Wolff type (also known as Wolff syndrome) is an extremely rare genetic condition that primarily affects brain development and intellectual function. It was first described in the medical literature and is characterized by intellectual disability along with certain physical features. People with this condition typically show delays in learning and development from early childhood. The condition falls under a group of disorders that combine intellectual disability with other body differences, which is why it is classified under the ICD-10 code Q87.0 (congenital malformat
At what age does Intellectual disability, Wolff type typically begin?
Typical onset of Intellectual disability, Wolff type is childhood. Age of onset can vary across affected individuals.