Idiopathic trachyonychia

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ORPHA:79153L60.3
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5Specialists8Treatment centers

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Overview

Idiopathic trachyonychia, also known as 'twenty-nail dystrophy' or 'sandpaper nails,' is a rare nail condition that causes the nails to look rough, dull, and ridged — similar in texture to sandpaper. The word 'trachyonychia' comes from the Greek word for rough. It can affect some or all 20 fingernails and toenails, though in many people only a few nails are involved. The nails may become brittle, thin, discolored (often grayish or opaque), and may have tiny pits or vertical ridges running along them. Despite how they look, the nails are usually not painful. The exact cause of idiopathic trachyonychia is not fully understood, which is why it is called 'idiopathic' — meaning no clear underlying cause has been found. In some cases, it is linked to other skin or immune conditions like alopecia areata, eczema, or psoriasis. It most often appears in children, though adults can be affected too. The good news is that idiopathic trachyonychia is generally a benign (harmless) condition. Many children see their nails improve on their own over time without any treatment. When treatment is needed, options include topical or injected steroids and other nail-strengthening therapies. The condition does not affect overall health or lifespan.

Key symptoms:

Rough, sandpaper-like texture on the nailsDull, opaque appearance of the nails instead of a normal shineVertical ridges or lines running along the nailsTiny pits or dents on the nail surfaceBrittle or fragile nails that break easilyThinning of the nailsGrayish or whitish discoloration of the nailsNails that curve or have an irregular shapeInvolvement of multiple nails at the same time (sometimes all 20)

Clinical phenotype terms (17)— hover any for plain English
Concave nailHP:0001598Nail pitsHP:0001803Ridged nailHP:0001807Fragile nailsHP:0001808Thin nailHP:0001816Fingernail dysplasiaHP:0100798Abnormal periungual morphologyHP:0100803Patchy alopeciaHP:0002232Circumungual hyperkeratosisHP:0008399Toenail dysplasiaHP:0100797VitiligoHP:0001045Autoimmune thrombocytopeniaHP:0001973Amyloid depositionHP:0011034
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Childhood

Begins in childhood, roughly ages 1 to 12

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Idiopathic trachyonychia.

View clinical trials →

No actively recruiting trials found for Idiopathic trachyonychia at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Idiopathic trachyonychia community →

Specialists

5 foundView all specialists →
AY
Ahu Yorulmaz
Specialist
1 Idiopathic trachyonychia publication
LB
Lorin A Bibb
HENSLEY, AR
Specialist
1 Idiopathic trachyonychia publication
MC
Mary Wu Chang
Specialist
1 Idiopathic trachyonychia publication
RX
Ruisi Xu
Specialist
1 Idiopathic trachyonychia publication
XY
Xiaohong Yu
FORT MYERS, FL
Specialist
1 Idiopathic trachyonychia publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Idiopathic trachyonychia.

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Community

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Latest news about Idiopathic trachyonychia

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Caregiver Resources

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Questions for your doctor

Bring these to your next appointment

  • Q1.Is my child's trachyonychia likely to go away on its own, and how long might that take?,Should we do any tests to check for related conditions like alopecia areata or psoriasis?,What treatment options are available, and do you recommend starting treatment now or waiting?,Are there any nail care routines or products that could help improve the appearance of the nails?,Could this condition be related to anything else going on in my child's health?,How often should we come back for follow-up appointments?,Is there anything my child should avoid doing to prevent the nails from getting worse?

Common questions about Idiopathic trachyonychia

What is Idiopathic trachyonychia?

Idiopathic trachyonychia, also known as 'twenty-nail dystrophy' or 'sandpaper nails,' is a rare nail condition that causes the nails to look rough, dull, and ridged — similar in texture to sandpaper. The word 'trachyonychia' comes from the Greek word for rough. It can affect some or all 20 fingernails and toenails, though in many people only a few nails are involved. The nails may become brittle, thin, discolored (often grayish or opaque), and may have tiny pits or vertical ridges running along them. Despite how they look, the nails are usually not painful. The exact cause of idiopathic trach

How is Idiopathic trachyonychia inherited?

Idiopathic trachyonychia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Idiopathic trachyonychia typically begin?

Typical onset of Idiopathic trachyonychia is childhood. Age of onset can vary across affected individuals.

Which specialists treat Idiopathic trachyonychia?

5 specialists and care centers treating Idiopathic trachyonychia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.