Overview
Hypotrichosis-intellectual disability, Lopes type (also sometimes called Lopes syndrome) is a very rare genetic condition that affects two main areas of the body: hair growth and brain development. 'Hypotrichosis' means having much less hair than normal, and this condition causes sparse or very thin hair on the scalp and sometimes other parts of the body from birth or early childhood. Along with the hair changes, people with this condition also have intellectual disability, meaning they may have difficulty with learning, communication, and daily tasks compared to others their age. This condition is present from birth or becomes noticeable in early childhood. The degree of intellectual disability can vary from mild to more significant, and some individuals may also have other features affecting their development. Because this is such a rare condition, the full range of symptoms is not completely understood yet. There is currently no cure for Hypotrichosis-intellectual disability, Lopes type. Treatment focuses on supporting learning and development through special education, speech therapy, and occupational therapy. Hair loss can be managed with cosmetic approaches if desired. Early intervention and a strong support network can make a meaningful difference in quality of life.
Also known as:
Key symptoms:
Very sparse or thin hair on the scalp (hypotrichosis)Intellectual disability or learning difficultiesDelayed speech and language developmentReduced hair on eyebrows or eyelashesDevelopmental delays in childhood milestones
Clinical phenotype terms (4)— hover any for plain English
Autosomal recessive
Passed on when both parents carry the same gene change; often skips generations
Infantile
Begins in infancy, roughly 1 month to 2 years old
Treatments
No FDA-approved treatments are currently listed for Hypotrichosis-intellectual disability, Lopes type.
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Specialists
View all specialists →No specialists are currently listed for Hypotrichosis-intellectual disability, Lopes type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Hypotrichosis-intellectual disability, Lopes type.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What genetic test should we do to confirm this diagnosis, and how long will results take?,What early intervention services should we start right away?,What level of intellectual disability does my child have, and what does that mean for their future?,Are there any other health problems we should watch for with this condition?,Should other family members be tested for this gene change?,Are there any clinical trials or research studies we could participate in?,What support services and resources are available in our area for children with intellectual disabilities?
Common questions about Hypotrichosis-intellectual disability, Lopes type
What is Hypotrichosis-intellectual disability, Lopes type?
Hypotrichosis-intellectual disability, Lopes type (also sometimes called Lopes syndrome) is a very rare genetic condition that affects two main areas of the body: hair growth and brain development. 'Hypotrichosis' means having much less hair than normal, and this condition causes sparse or very thin hair on the scalp and sometimes other parts of the body from birth or early childhood. Along with the hair changes, people with this condition also have intellectual disability, meaning they may have difficulty with learning, communication, and daily tasks compared to others their age. This condit
How is Hypotrichosis-intellectual disability, Lopes type inherited?
Hypotrichosis-intellectual disability, Lopes type follows a autosomal recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Hypotrichosis-intellectual disability, Lopes type typically begin?
Typical onset of Hypotrichosis-intellectual disability, Lopes type is infantile. Age of onset can vary across affected individuals.