High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement

High-grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement is an aggressive type of blood cancer that affects a type of white blood cell called a B-cell. This disease is sometimes called 'double-hit' or 'triple-hit' lymphoma, depending on how many gene changes are involved. When two genes are rearranged (most often MYC and BCL2, or MYC and BCL6), it is called double-hit lymphoma. When all three genes are rearranged, it is called triple-hit lymphoma. These names come from the fact that the cancer cells have two or three specific genetic 'hits' or changes that make the cancer grow very fast. This lymphoma usually starts in the lymph nodes — small glands found throughout the body that are part of the immune system — but it can spread quickly to other organs, including the bone marrow, liver, and brain. Because it grows so rapidly, people often notice symptoms within weeks. Common symptoms include swollen lymph nodes (lumps under the skin in the neck, armpits, or groin), extreme tiredness, unexplained weight loss, drenching night sweats, and fever. Some people also experience belly pain or swelling if the lymphoma affects organs in the abdomen. Treatment for this lymphoma is intensive and typically involves combination chemotherapy regimens. Standard treatments like R-CHOP (a combination of rituximab plus four chemotherapy drugs) are often used, though many specialists prefer more intensive regimens such as DA-EPOCH-R. Because this cancer is so aggressive, treatment usually begins very quickly after diagnosis. Research into newer therapies, including CAR-T cell therapy and targeted drugs, is ongoing and offering new hope for patients.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Bring these to your next appointment

• Q1.Which genes are rearranged in my lymphoma — is it double-hit or triple-hit — and how does that affect my treatment plan?,Which chemotherapy regimen do you recommend for me, and why — DA-EPOCH-R or R-CHOP or something else?,Will I need treatment to protect my brain from the cancer, and what does that involve?,What are the chances that my cancer will respond to treatment, and what happens if it comes back?,Am I a candidate for a stem cell transplant or CAR-T cell therapy, either now or in the future?,Are there any clinical trials I should consider?,What support services — such as social work, mental health counseling, or financial assistance — are available to me and my family?

Common questions about High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement

Related conditions

Other rare diseases commonly researched alongside High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement.

• Burkitt lymphoma→
• Primary mediastinal large B-cell lymphoma→