Overview
Hereditary atrial tachyarrhythmia with infra-Hisian cardiac conduction disease is a very rare inherited heart rhythm disorder. In this condition, the heart's electrical system does not work properly in two ways. First, the upper chambers of the heart (the atria) beat too fast, which is called atrial tachyarrhythmia. Second, there is a problem with how electrical signals travel through the lower part of the heart's conduction system, specifically below a structure called the bundle of His. This area is responsible for sending electrical signals from the upper chambers to the lower chambers (ventricles), so when it doesn't work correctly, the heartbeat can become dangerously slow or irregular. People with this condition may experience episodes of rapid heartbeat (palpitations), dizziness, fainting, fatigue, and shortness of breath. Because the disease affects both the fast and slow parts of the heart's rhythm, patients can swing between having a heart rate that is too fast and one that is too slow. This combination makes treatment particularly challenging. Treatment typically focuses on managing symptoms and preventing dangerous heart rhythms. This may include medications to control heart rate, blood thinners to reduce stroke risk from atrial arrhythmias, and in many cases, implantation of a pacemaker to address the slow conduction problem. Catheter ablation procedures may also be considered for the fast rhythm component. Because this is a hereditary condition, family screening with electrocardiograms (ECGs) and genetic testing is recommended for close relatives.
Key symptoms:
Rapid or racing heartbeat (palpitations)Fainting or near-fainting episodesDizziness or lightheadednessUnexplained fatigue or tirednessShortness of breathChest discomfort or tightnessExercise intoleranceIrregular heartbeatSlow heart rate (bradycardia)Episodes of fast heart rate followed by pauses
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease.
Community
No community posts yet. Be the first to share your experience with Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease.
Start the conversation →Latest news about Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease
No recent news articles for Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe is the conduction problem in my heart, and do I need a pacemaker now or in the future?,What medications are safe for me, and which ones should I avoid?,Should my family members be tested for this condition?,What physical activities or exercises are safe for me?,How often will I need follow-up appointments and heart monitoring?,What are the warning signs that I should go to the emergency room?,Are there any clinical trials or new treatments being studied for this condition?
Common questions about Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease
What is Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease?
Hereditary atrial tachyarrhythmia with infra-Hisian cardiac conduction disease is a very rare inherited heart rhythm disorder. In this condition, the heart's electrical system does not work properly in two ways. First, the upper chambers of the heart (the atria) beat too fast, which is called atrial tachyarrhythmia. Second, there is a problem with how electrical signals travel through the lower part of the heart's conduction system, specifically below a structure called the bundle of His. This area is responsible for sending electrical signals from the upper chambers to the lower chambers (ven
How is Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease inherited?
Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.