Overview
Hallux varus-preaxial polysyndactyly syndrome is an extremely rare genetic condition that affects the development of the hands and feet. The name describes its main features: hallux varus means the big toe is angled away from the other toes (pointing inward), preaxial polydactyly means there are extra fingers or toes on the thumb or big toe side of the hands or feet, and syndactyly means some fingers or toes are fused or webbed together. These abnormalities are present at birth and can affect one or both sides of the body. Because this condition is so rare, only a small number of families have been described in the medical literature. The skeletal differences in the hands and feet can range from mild to more noticeable, and the severity can vary even among members of the same family. Importantly, this condition primarily affects the limbs and does not typically cause problems with thinking, learning, or internal organs. Treatment is mainly surgical and supportive. Orthopedic surgeons and hand or foot specialists can correct the extra digits, separate fused fingers or toes, and improve the alignment of the big toe. Physical therapy and occupational therapy may also help with hand function and mobility after surgery. Early evaluation by a clinical geneticist is recommended to confirm the diagnosis and provide genetic counseling to the family.
Also known as:
Key symptoms:
Big toe angled inward (away from other toes)Extra fingers or toes on the thumb or big toe sideWebbed or fused fingers or toesAbnormal shape or alignment of the big toeBroad or duplicated thumbsFoot deformity affecting walking or shoe fittingAsymmetric involvement of hands or feetShort or abnormally shaped bones in the fingers or toes
Clinical phenotype terms (2)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Hallux varus-preaxial polysyndactyly syndrome.
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Specialists
View all specialists →No specialists are currently listed for Hallux varus-preaxial polysyndactyly syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Hallux varus-preaxial polysyndactyly syndrome.
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Caregiver Resources
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe are my child's hand and foot differences, and what surgeries are recommended?,At what age should surgery be performed for the best outcome?,Will my child need more than one surgery as they grow?,What physical or occupational therapy will be needed after surgery?,Is genetic testing available to confirm the diagnosis and help with family planning?,What is the chance that future children could also be affected?,Are there any other health problems we should watch for with this condition?
Common questions about Hallux varus-preaxial polysyndactyly syndrome
What is Hallux varus-preaxial polysyndactyly syndrome?
Hallux varus-preaxial polysyndactyly syndrome is an extremely rare genetic condition that affects the development of the hands and feet. The name describes its main features: hallux varus means the big toe is angled away from the other toes (pointing inward), preaxial polydactyly means there are extra fingers or toes on the thumb or big toe side of the hands or feet, and syndactyly means some fingers or toes are fused or webbed together. These abnormalities are present at birth and can affect one or both sides of the body. Because this condition is so rare, only a small number of families hav
How is Hallux varus-preaxial polysyndactyly syndrome inherited?
Hallux varus-preaxial polysyndactyly syndrome follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Hallux varus-preaxial polysyndactyly syndrome typically begin?
Typical onset of Hallux varus-preaxial polysyndactyly syndrome is neonatal. Age of onset can vary across affected individuals.