Overview
Focal facial dermal dysplasia type II (FFDD II), also known as Brauer syndrome, is a rare inherited skin condition that primarily affects the skin on the face, especially around the temples. People with this condition are born with small, round, scar-like areas of thin or absent skin on both sides of the face, typically near the temples. These lesions look like small depressions or puckered scars and are present from birth. The underlying tissue beneath these skin defects may also be thinner than normal. FFDD type II is one of several types of focal facial dermal dysplasia. What makes type II distinct is that the skin lesions are usually limited to the temple areas and are inherited in an autosomal dominant pattern, meaning only one copy of the altered gene is needed to cause the condition. Unlike some other types of FFDD, type II is generally not associated with other major birth defects or systemic health problems. There is no cure for FFDD type II, and treatment is mainly cosmetic. The scar-like marks are usually stable and do not worsen over time. Some individuals may choose cosmetic procedures such as skin grafting or laser treatments to improve the appearance of the affected areas, though many people live comfortably without any intervention. The condition does not typically affect overall health or lifespan, and most individuals lead normal, healthy lives.
Key symptoms:
Scar-like skin depressions on the temples from birthThin or absent skin patches on the facePuckered or dimpled appearance of the skin near the templesSkin lesions that look like round or oval scarsThinning of the tissue beneath the affected skin areasLesions usually present on both sides of the facePossible mild hair loss in the affected skin areas
Clinical phenotype terms (13)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Focal facial dermal dysplasia type II.
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Specialists
View all specialists →No specialists are currently listed for Focal facial dermal dysplasia type II.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Focal facial dermal dysplasia type II.
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Caregiver Resources
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Social Security Disability
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Questions for your doctor
Bring these to your next appointment
- Q1.Can you confirm that my child's skin lesions are FFDD type II and not another condition?,Is genetic testing available to confirm the diagnosis?,What cosmetic treatment options are available, and at what age can they be considered?,Will the skin lesions change or worsen as my child grows?,What is the chance of passing this condition to future children?,Are there any other health problems I should watch for?,Can you recommend psychological support resources for coping with visible facial differences?
Common questions about Focal facial dermal dysplasia type II
What is Focal facial dermal dysplasia type II?
Focal facial dermal dysplasia type II (FFDD II), also known as Brauer syndrome, is a rare inherited skin condition that primarily affects the skin on the face, especially around the temples. People with this condition are born with small, round, scar-like areas of thin or absent skin on both sides of the face, typically near the temples. These lesions look like small depressions or puckered scars and are present from birth. The underlying tissue beneath these skin defects may also be thinner than normal. FFDD type II is one of several types of focal facial dermal dysplasia. What makes type II
How is Focal facial dermal dysplasia type II inherited?
Focal facial dermal dysplasia type II follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Focal facial dermal dysplasia type II typically begin?
Typical onset of Focal facial dermal dysplasia type II is neonatal. Age of onset can vary across affected individuals.