Overview
Familial osteodysplasia, Anderson type, is an extremely rare inherited bone disorder that affects how bones and other tissues develop. This condition is sometimes also called Anderson-type familial osteodysplasia. It was first described in a small number of families and involves abnormal bone formation (osteodysplasia) along with other features that can affect multiple body systems. People with this condition typically show skeletal abnormalities that may include unusual bone shape, thinning of bones, and changes in the skull and facial bones. Additional features can include skin abnormalities, dental problems, and in some cases, hearing difficulties. The severity of symptoms can vary even among members of the same family. Because this disease is so rare, there is very limited information about its full range of symptoms and long-term outcomes. There is currently no specific cure or targeted treatment. Management focuses on addressing individual symptoms as they arise, which may include orthopedic care for bone problems, dental treatment, and monitoring for complications. Patients benefit from a team of specialists who can coordinate care across the different body systems that may be affected.
Key symptoms:
Abnormal bone shape and structureThinning or fragile bonesUnusual facial featuresSkull bone abnormalitiesDental problems or missing teethSkin changes or abnormalitiesHearing loss or hearing difficultiesShort stature or growth delaysJoint stiffness or limited joint movementNail abnormalities
Clinical phenotype terms (31)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for Familial osteodysplasia, Anderson type.
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Specialists
View all specialists →No specialists are currently listed for Familial osteodysplasia, Anderson type.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Familial osteodysplasia, Anderson type.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe is my child's bone involvement, and what complications should I watch for?,Should we pursue genetic testing, and what might it tell us?,How often should we schedule skeletal X-rays and hearing tests?,Are there any activities my child should avoid to protect their bones?,What dental specialists should be involved in my child's care?,Is there any ongoing research or clinical trials for this condition?,What is the expected long-term outlook for someone with this condition?
Common questions about Familial osteodysplasia, Anderson type
What is Familial osteodysplasia, Anderson type?
Familial osteodysplasia, Anderson type, is an extremely rare inherited bone disorder that affects how bones and other tissues develop. This condition is sometimes also called Anderson-type familial osteodysplasia. It was first described in a small number of families and involves abnormal bone formation (osteodysplasia) along with other features that can affect multiple body systems. People with this condition typically show skeletal abnormalities that may include unusual bone shape, thinning of bones, and changes in the skull and facial bones. Additional features can include skin abnormalitie
How is Familial osteodysplasia, Anderson type inherited?
Familial osteodysplasia, Anderson type follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Familial osteodysplasia, Anderson type typically begin?
Typical onset of Familial osteodysplasia, Anderson type is childhood. Age of onset can vary across affected individuals.