Familial multiple discoid fibromas

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ORPHA:538756OMIM:190340D23.9
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Overview

Familial multiple discoid fibromas is a very rare inherited skin condition where multiple firm, benign (non-cancerous) growths called discoid fibromas develop on the skin. These growths are made up of extra fibrous tissue and typically appear as small, round, flat or slightly raised bumps on the skin. The condition is also sometimes referred to as familial cutaneous collagenoma or multiple fibrofolliculomas in related contexts, though these may overlap with similar but distinct syndromes. The skin growths are usually painless and do not cause serious health problems on their own, but their appearance can be a source of cosmetic concern for patients. Because this condition runs in families, it is thought to be passed down through generations in an autosomal dominant pattern, meaning only one copy of the changed gene is enough to cause the condition. The growths tend to appear in adulthood, though the exact age can vary. Currently, there is no cure for familial multiple discoid fibromas. Treatment focuses on managing the appearance of the skin lesions, often through minor surgical removal or other cosmetic procedures. Regular monitoring by a dermatologist is recommended to track any changes in the growths over time.

Also known as:

Key symptoms:

Multiple small, firm, round skin bumps (discoid fibromas)Bumps that are flat or slightly raised above the skin surfaceSkin growths that are usually painlessGrowths appearing in multiple locations on the bodySkin lesions that tend to increase in number over timeCosmetic changes to the skin's appearance

Inheritance

Autosomal dominant

Passed on from just one parent; each child has about a 50% chance of inheriting it

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗OMIM ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Familial multiple discoid fibromas.

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No actively recruiting trials found for Familial multiple discoid fibromas at this time.

New trials open frequently. Follow this disease to get notified.

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No specialists are currently listed for Familial multiple discoid fibromas.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Familial multiple discoid fibromas.

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Community

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Caregiver Resources

NORD Caregiver Resources

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Mental Health Support

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Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What type of genetic testing should I have to find out the cause of my condition?,How often should I see a dermatologist to monitor my skin growths?,What treatment options are available to reduce the appearance of my skin bumps?,What is the chance that my children will inherit this condition?,Are there any signs I should watch for that would mean a growth needs urgent attention?,Should other family members be evaluated or tested for this condition?,Are there any clinical trials or research studies I could participate in?

Common questions about Familial multiple discoid fibromas

What is Familial multiple discoid fibromas?

Familial multiple discoid fibromas is a very rare inherited skin condition where multiple firm, benign (non-cancerous) growths called discoid fibromas develop on the skin. These growths are made up of extra fibrous tissue and typically appear as small, round, flat or slightly raised bumps on the skin. The condition is also sometimes referred to as familial cutaneous collagenoma or multiple fibrofolliculomas in related contexts, though these may overlap with similar but distinct syndromes. The skin growths are usually painless and do not cause serious health problems on their own, but their app

How is Familial multiple discoid fibromas inherited?

Familial multiple discoid fibromas follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Familial multiple discoid fibromas typically begin?

Typical onset of Familial multiple discoid fibromas is adult. Age of onset can vary across affected individuals.