Familial isolated clinodactyly of fingers

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Overview

Familial isolated clinodactyly of fingers is a condition where one or more fingers curve or bend sideways, most commonly affecting the fifth finger (pinky finger). The word 'clinodactyly' comes from Greek words meaning 'bent finger.' In this familial form, the condition runs in families and occurs on its own — meaning it is not part of a larger syndrome or associated with other birth differences. The curving is caused by an abnormally shaped bone (usually a wedge-shaped middle bone, called the middle phalanx) in the affected finger. The condition is present from birth and is usually noticed in infancy or early childhood as the hands grow. Most people with familial isolated clinodactyly have mild curving that does not cause pain or significant problems with hand function. The degree of bending can vary from barely noticeable to more pronounced. Both hands may be affected, or just one. Because this is an isolated finding, children with this condition typically develop normally in all other ways. Treatment is usually not needed for mild cases. If the curving is severe enough to interfere with hand function or grip, an orthopedic hand surgeon may recommend corrective surgery. Physical or occupational therapy may also be helpful in some cases. Overall, this is considered a benign condition with an excellent outlook, and most people live completely normal lives without any limitations.

Key symptoms:

Sideways curving of one or more fingersMost commonly affects the pinky (fifth) fingerCurving may affect one or both handsShortened or wedge-shaped finger boneFinger may appear crooked or angled inwardUsually painlessMild difficulty with fine grip in severe casesCosmetic concern about finger appearance

Inheritance

Autosomal dominant

Passed on from just one parent; each child has about a 50% chance of inheriting it

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Familial isolated clinodactyly of fingers.

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No actively recruiting trials found for Familial isolated clinodactyly of fingers at this time.

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No specialists are currently listed for Familial isolated clinodactyly of fingers.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Familial isolated clinodactyly of fingers.

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Community

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Questions for your doctor

Bring these to your next appointment

  • Q1.Is my child's clinodactyly truly isolated, or could it be part of a syndrome?,Should we get genetic testing to rule out other conditions?,How severe is the curving, and is it likely to get worse as my child grows?,Will my child need surgery, and if so, when is the best time?,Will this affect my child's ability to write, play sports, or play musical instruments?,What is the chance of passing this on to future children?,Should we see a hand specialist or occupational therapist?

Common questions about Familial isolated clinodactyly of fingers

What is Familial isolated clinodactyly of fingers?

Familial isolated clinodactyly of fingers is a condition where one or more fingers curve or bend sideways, most commonly affecting the fifth finger (pinky finger). The word 'clinodactyly' comes from Greek words meaning 'bent finger.' In this familial form, the condition runs in families and occurs on its own — meaning it is not part of a larger syndrome or associated with other birth differences. The curving is caused by an abnormally shaped bone (usually a wedge-shaped middle bone, called the middle phalanx) in the affected finger. The condition is present from birth and is usually noticed in

How is Familial isolated clinodactyly of fingers inherited?

Familial isolated clinodactyly of fingers follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Familial isolated clinodactyly of fingers typically begin?

Typical onset of Familial isolated clinodactyly of fingers is neonatal. Age of onset can vary across affected individuals.