Overview
Eyebrow duplication-syndactyly syndrome is an extremely rare genetic condition that is present from birth. As the name suggests, the two main features of this syndrome are duplication (doubling) of the eyebrows and syndactyly, which means that some fingers or toes are fused or webbed together. The eyebrow duplication can range from a thickened, bushy appearance to what looks like two distinct rows of eyebrow hair. The syndactyly typically involves the soft tissue between fingers or toes, though in some cases the bones may also be joined. Because this condition is so rare, with only a handful of cases described in the medical literature, the full range of possible symptoms and the underlying genetic cause are not yet well understood. There is no cure for this syndrome, and treatment focuses on managing the individual features. Surgery may be considered to separate fused fingers or toes and improve hand or foot function. Cosmetic approaches can address the eyebrow duplication if desired. Affected individuals should be followed by a team of specialists to monitor for any additional features that may be associated with the condition. The long-term outlook depends on the severity of the features and how well they respond to treatment.
Key symptoms:
Double or duplicated eyebrowsThickened or unusually bushy eyebrowsWebbed or fused fingersWebbed or fused toesUnusual facial appearancePossible limb abnormalities
Variable
Can be inherited in different ways depending on the underlying gene
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Eyebrow duplication-syndactyly syndrome.
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Specialists
View all specialists →No specialists are currently listed for Eyebrow duplication-syndactyly syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Eyebrow duplication-syndactyly syndrome.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the best age for my child to have surgery to separate fused fingers or toes?,Are there any other health problems we should watch for with this condition?,Is genetic testing available to find the cause, and would it help our family?,What are the risks and expected outcomes of syndactyly release surgery?,Should we see any other specialists?,What are the chances that future children could also be affected?,Are there any clinical studies or research programs we could participate in?
Common questions about Eyebrow duplication-syndactyly syndrome
What is Eyebrow duplication-syndactyly syndrome?
Eyebrow duplication-syndactyly syndrome is an extremely rare genetic condition that is present from birth. As the name suggests, the two main features of this syndrome are duplication (doubling) of the eyebrows and syndactyly, which means that some fingers or toes are fused or webbed together. The eyebrow duplication can range from a thickened, bushy appearance to what looks like two distinct rows of eyebrow hair. The syndactyly typically involves the soft tissue between fingers or toes, though in some cases the bones may also be joined. Because this condition is so rare, with only a handful o
At what age does Eyebrow duplication-syndactyly syndrome typically begin?
Typical onset of Eyebrow duplication-syndactyly syndrome is neonatal. Age of onset can vary across affected individuals.