Overview
Euryblepharon is a rare congenital eyelid anomaly characterized by an abnormally wide horizontal palpebral fissure (the opening between the upper and lower eyelids). The condition results from a lateral enlargement of the eyelid aperture, which can affect one or both eyes. In euryblepharon, the eyelids — particularly the lower lid — may be unable to fully cover and protect the eye, leading to exposure of the conjunctiva and cornea. This inadequate eyelid closure can result in chronic eye irritation, dryness, tearing (epiphora), conjunctival injection, and in more severe cases, exposure keratopathy (corneal damage due to drying). Euryblepharon primarily affects the ocular and periorbital structures. It may occur as an isolated finding or in association with other congenital anomalies, including other eyelid malformations such as ectropion (outward turning of the eyelid), telecanthus, or blepharophimosis. It has also been reported in the context of broader syndromic conditions. The condition is typically present at birth and is usually recognized in the neonatal or early infantile period. Management of euryblepharon depends on the severity of symptoms and the degree of corneal exposure. Mild cases may be managed conservatively with lubricating eye drops and ointments to protect the corneal surface. More significant cases, particularly those with corneal exposure or progressive keratopathy, may require surgical correction. Surgical approaches typically involve lateral canthoplasty or other eyelid-tightening procedures aimed at reducing the palpebral fissure width and improving eyelid coverage of the globe. Early ophthalmologic evaluation and monitoring are important to prevent corneal complications.
Variable
Can be inherited in different ways depending on the underlying gene
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Euryblepharon.
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Specialists
View all specialists →No specialists are currently listed for Euryblepharon.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Euryblepharon.
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Common questions about Euryblepharon
What is Euryblepharon?
Euryblepharon is a rare congenital eyelid anomaly characterized by an abnormally wide horizontal palpebral fissure (the opening between the upper and lower eyelids). The condition results from a lateral enlargement of the eyelid aperture, which can affect one or both eyes. In euryblepharon, the eyelids — particularly the lower lid — may be unable to fully cover and protect the eye, leading to exposure of the conjunctiva and cornea. This inadequate eyelid closure can result in chronic eye irritation, dryness, tearing (epiphora), conjunctival injection, and in more severe cases, exposure keratop
At what age does Euryblepharon typically begin?
Typical onset of Euryblepharon is neonatal. Age of onset can vary across affected individuals.