Euryblepharon

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:99172Q10.1
Who is this for?
Show terms as
8Treatment centers

Where are you in your journey?

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Euryblepharon is a rare congenital eyelid anomaly characterized by an abnormally wide horizontal palpebral fissure (the opening between the upper and lower eyelids). The condition results from a lateral enlargement of the eyelid aperture, which can affect one or both eyes. In euryblepharon, the eyelids — particularly the lower lid — may be unable to fully cover and protect the eye, leading to exposure of the conjunctiva and cornea. This inadequate eyelid closure can result in chronic eye irritation, dryness, tearing (epiphora), conjunctival injection, and in more severe cases, exposure keratopathy (corneal damage due to drying). Euryblepharon primarily affects the ocular and periorbital structures. It may occur as an isolated finding or in association with other congenital anomalies, including other eyelid malformations such as ectropion (outward turning of the eyelid), telecanthus, or blepharophimosis. It has also been reported in the context of broader syndromic conditions. The condition is typically present at birth and is usually recognized in the neonatal or early infantile period. Management of euryblepharon depends on the severity of symptoms and the degree of corneal exposure. Mild cases may be managed conservatively with lubricating eye drops and ointments to protect the corneal surface. More significant cases, particularly those with corneal exposure or progressive keratopathy, may require surgical correction. Surgical approaches typically involve lateral canthoplasty or other eyelid-tightening procedures aimed at reducing the palpebral fissure width and improving eyelid coverage of the globe. Early ophthalmologic evaluation and monitoring are important to prevent corneal complications.

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Euryblepharon.

View clinical trials →

No actively recruiting trials found for Euryblepharon at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Euryblepharon community →

No specialists are currently listed for Euryblepharon.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Euryblepharon.

Search all travel grants →NORD Financial Assistance ↗

Community

Open EuryblepharonForum →

No community posts yet. Be the first to share your experience with Euryblepharon.

Start the conversation →

Latest news about Euryblepharon

No recent news articles for Euryblepharon.

Follow this condition to be notified when news becomes available.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Euryblepharon

What is Euryblepharon?

Euryblepharon is a rare congenital eyelid anomaly characterized by an abnormally wide horizontal palpebral fissure (the opening between the upper and lower eyelids). The condition results from a lateral enlargement of the eyelid aperture, which can affect one or both eyes. In euryblepharon, the eyelids — particularly the lower lid — may be unable to fully cover and protect the eye, leading to exposure of the conjunctiva and cornea. This inadequate eyelid closure can result in chronic eye irritation, dryness, tearing (epiphora), conjunctival injection, and in more severe cases, exposure keratop

At what age does Euryblepharon typically begin?

Typical onset of Euryblepharon is neonatal. Age of onset can vary across affected individuals.