Episodic ataxia type 3

Episodic ataxia type 3 (EA3) is a very rare inherited neurological condition that causes sudden, repeated episodes of poor coordination and balance (called ataxia). During these episodes, a person may feel unsteady, have trouble walking, and experience dizziness or vertigo — a spinning sensation. Episodes can last from a few minutes to several hours and may happen many times a day or only occasionally. Between episodes, most people feel completely normal, which is one of the hallmark features of this condition. EA3 belongs to a group of conditions called episodic ataxias, all of which share this pattern of coming-and-going coordination problems. EA3 is thought to be caused by changes in a gene that affects how nerve cells communicate, though the exact gene responsible is still being studied and confirmed. Triggers for episodes can include stress, fatigue, sudden movement, or illness. Treatment focuses on reducing how often and how severe the episodes are. Medications such as acetazolamide, which is used for other types of episodic ataxia, may be tried, though evidence specific to EA3 is limited. There is currently no cure. Most people with EA3 can live relatively normal lives between episodes, but the unpredictable nature of attacks can affect daily activities, work, and quality of life.

Bring these to your next appointment

• Q1.What type of genetic testing do you recommend to confirm or better understand my diagnosis?,Should I try acetazolamide, and what are the risks and benefits for my specific situation?,Are there known triggers I should avoid, and how do I identify my personal triggers?,What should I do — and what should my family do — when an episode starts?,Is it safe for me to drive or work in my current job?,Are there any clinical trials or research studies I could participate in?,What are the chances that my children or other family members could have this condition?

Common questions about Episodic ataxia type 3