Eisenmenger syndrome

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ORPHA:97214I27.2
Who is this for?
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2Active trials22Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Clinical phenotype terms— hover any for plain English:

Supraventricular tachycardiaHP:0004755Atrial fibrillationHP:0005110Supraventricular arrhythmiaHP:0005115Increased pulmonary vascular resistanceHP:0005317ClubbingHP:0001217
Orphanet ↗NORD ↗

FDA & Trial Timeline

3 events
Sep 2026Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s Syndrome

Philipps University Marburg — PHASE2

TrialNOT YET RECRUITING
Oct 2025A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy

Kazuya Hosokawa — PHASE4

TrialRECRUITING
Jun 2022Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger Syndrome

University of Sao Paulo General Hospital — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Eisenmenger syndrome.

2 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

2 recruitingView all trials with filters →
Phase 41 trial
A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
Phase 4
Actively Recruiting
· Sites: Fukuoka, Not Required For This Country; Fukuoka +8 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A1 trial
Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger Syndrome
N/A
Actively Recruiting
PI: Antonio Augusto Barbosa Lopes, MD (InCor Heart Institute) · Sites: São Paulo · Age: 10–80 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

22 foundView all specialists →
LM
Lars Soendergaard, MD
Specialist
PI on 1 active trial
SM
Sanjay Tyagi, M.D;D.M
Specialist
PI on 1 active trial
SM
Saibal Mukhopadhyay, M.D;D.M
Specialist
PI on 1 active trial
AM
Antonio Augusto Barbosa Lopes, MD
MONROVIA, CA
Specialist
PI on 1 active trial
SP
Stephan Rosenkranz, MD, PhD
Specialist
PI on 1 active trial
IM
Ingram Schulze-Neick, MD
Specialist
PI on 1 active trial
JF
Jamil A Aboulhosn, MD, FACC
LOS ANGELES, CA
Specialist
PI on 1 active trial
HM
HASCOET SEBASTIEN, MD
Specialist
PI on 1 active trial
LP
Laion Gonzaga, PT
Specialist
PI on 1 active trial
WM
Wendy M. Book, MD
ATLANTA, GA
Specialist
PI on 2 active trials
DP
David Pittrow, MD, PhD
Specialist
PI on 3 active trials
MP
Marius M Hoeper, MD, PhD
Specialist
PI on 1 active trial
MP
Marion Delcroix, MD, PhD
Specialist
PI on 1 active trial
OP
Oliver Distler, MD, PhD
Specialist
PI on 1 active trial
DP
Dario Vizza, MD, PhD
Specialist
PI on 1 active trial
CP
Christian Opitz, MD, PhD
Specialist
PI on 1 active trial
EP
Ekkehard Grünig, MD, PhD
Specialist
PI on 1 active trial
KP
Karen Olsson, MD, PhD
Specialist
PI on 1 active trial
MP
Matthias Gorenflo, MD, PhD
Specialist
PI on 1 active trial
AP
Ardeschir H. Ghofrani, MD, PhD
Specialist
PI on 1 active trial
HP
Harald Kaemmerer, MD, PhD
Specialist
PI on 1 active trial
GM
Gary Palmer, MD, MBA
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Eisenmenger syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Eisenmenger syndrome

Disease timeline:

New recruiting trial: Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger Syndrome

A new clinical trial is recruiting patients for Eisenmenger syndrome

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Eisenmenger syndrome

Are there clinical trials for Eisenmenger syndrome?

Yes — 2 recruiting clinical trials are currently listed for Eisenmenger syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Eisenmenger syndrome?

22 specialists and care centers treating Eisenmenger syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.