Early-onset posterior subcapsular cataract

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ORPHA:441447OMIM:116600H26.0
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Overview

Early-onset posterior subcapsular cataract (EOPSC) is a rare inherited eye condition where the lens of the eye becomes cloudy at an unusually young age — often in childhood, adolescence, or early adulthood. The lens sits inside the eye and helps focus light onto the retina. In this condition, cloudiness develops specifically at the back surface of the lens (the posterior subcapsular region), which is the area most important for sharp, detailed vision. This location makes the condition particularly disruptive to everyday tasks like reading, using a phone, or driving, especially in bright light or when looking at lit screens. The main symptom is blurred or hazy vision that gets worse over time. People often notice glare and halos around lights, difficulty reading fine print, and reduced vision in bright conditions. Unlike age-related cataracts that typically appear after age 60, EOPSC can appear in children or young adults, sometimes affecting both eyes. It may occur on its own or as part of a broader genetic syndrome. Treatment is primarily surgical. Cataract surgery to remove the cloudy lens and replace it with an artificial lens (intraocular lens implant) is highly effective and is the standard of care. When performed at the right time, surgery can restore good vision. Regular monitoring by an eye specialist is important to decide the best timing for surgery and to check for any related eye problems.

Key symptoms:

Blurred or hazy visionGlare and halos around lights, especially at nightDifficulty reading small printReduced vision in bright light or sunlightSensitivity to light (photophobia)Frequent changes in glasses or contact lens prescriptionCloudy or milky appearance of the lens visible to others in severe casesDouble vision in one eyeFaded or washed-out appearance of colors

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗OMIM ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Early-onset posterior subcapsular cataract.

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No actively recruiting trials found for Early-onset posterior subcapsular cataract at this time.

New trials open frequently. Follow this disease to get notified.

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No specialists are currently listed for Early-onset posterior subcapsular cataract.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Early-onset posterior subcapsular cataract.

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Community

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Which gene or genes might be causing this cataract, and should our family have genetic testing?,How quickly is the cataract likely to progress, and when would you recommend surgery?,What type of artificial lens would be used, and how will it be chosen for a growing child's eye?,What is the risk of lazy eye (amblyopia), and how will we prevent or treat it?,Are there any other eye problems I or my child should be monitored for, such as glaucoma or retinal issues?,What are the chances that other family members will develop this condition?,Are there any clinical trials or new treatments we should know about?

Common questions about Early-onset posterior subcapsular cataract

What is Early-onset posterior subcapsular cataract?

Early-onset posterior subcapsular cataract (EOPSC) is a rare inherited eye condition where the lens of the eye becomes cloudy at an unusually young age — often in childhood, adolescence, or early adulthood. The lens sits inside the eye and helps focus light onto the retina. In this condition, cloudiness develops specifically at the back surface of the lens (the posterior subcapsular region), which is the area most important for sharp, detailed vision. This location makes the condition particularly disruptive to everyday tasks like reading, using a phone, or driving, especially in bright light