Eales disease

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ORPHA:40923H35.0
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16Specialists8Treatment centers

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Overview

Eales disease is a rare eye condition that mainly affects the blood vessels in the retina — the light-sensitive layer at the back of the eye. It was first described by British ophthalmologist Henry Eales in the 1880s. The disease causes inflammation of the retinal blood vessels (a process called retinal vasculitis), which can lead to abnormal new blood vessel growth, bleeding inside the eye, and in serious cases, vision loss. It is sometimes called idiopathic retinal vasculitis or peripheral retinal periphlebitis, because the inflammation tends to start in the outer (peripheral) parts of the retina. The disease usually progresses in stages. Early on, the blood vessels become inflamed and may leak fluid. Later, the body tries to grow new blood vessels to compensate, but these new vessels are fragile and prone to bleeding into the gel-like fluid inside the eye (called the vitreous). This bleeding — known as vitreous hemorrhage — is often what causes sudden, noticeable vision problems. Scar tissue can also form, which may pull on the retina and cause it to detach. The most common symptoms include blurry vision, floaters (dark spots or cobweb-like shapes drifting across your vision), sudden loss of vision in one or both eyes, and redness or discomfort in the eye. Both eyes are affected in many patients, though often at different times. Treatment focuses on controlling inflammation, sealing leaking blood vessels with laser therapy, and in advanced cases, surgery to remove blood from the eye. With early diagnosis and proper treatment, many people can preserve useful vision.

Also known as:

Key symptoms:

Blurry or hazy visionFloaters — dark spots, threads, or cobweb shapes drifting in your field of visionSudden loss of vision in one or both eyesRedness of the eyeEye discomfort or mild painSeeing flashes of lightReduced vision in dim lightingGradual narrowing of the visual fieldRecurrent episodes of bleeding inside the eyeVision that seems to come and go

Clinical phenotype terms (30)— hover any for plain English
Vitreous hemorrhageHP:0007902Retinal vasculitisHP:0025188Multifocal cerebral white matter abnormalitiesHP:0007052Tractional retinal detachmentHP:0007917Rubeosis iridisHP:0011497Cystoid macular edemaHP:0011505VitritisHP:0011531Anterior uveitisHP:0012122Rhegmatogenous retinal detachmentHP:0012230Retinal thinning on OCTHP:0030329Vitreous hazeHP:0030652
Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Eales disease.

View clinical trials →

No actively recruiting trials found for Eales disease at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Eales disease community →

Specialists

16 foundView all specialists →
CM
Christina J. Flaxel, MD
PORTLAND, OR
Specialist
PI on 1 active trial
XZ
Xin-Yu Zhao
Specialist
1 Eales disease publication
YC
You-Xin Chen
Specialist
1 Eales disease publication
SL
Seung Min Lee
Specialist
1 Eales disease publication
JJ
Jae Hoon Jung
Specialist
1 Eales disease publication
KB
Kailey Bae
Specialist
1 Eales disease publication
CA
Cheldon Ann Alcantara
STOCKTON, CA
Specialist
1 Eales disease publication
JK
Jonathan Kim
Specialist
1 Eales disease publication
CT
Crystal Tsui
LA JOLLA, CA
Specialist
1 Eales disease publication
VV
Vishwanath Venketaraman
Specialist
1 Eales disease publication
SC
Shi-Yu Cheng
BOTHELL, WA
Specialist
1 Eales disease publication
WZ
Wen-Fei Zhang
Specialist
1 Eales disease publication
LM
Li-Hui Meng
Specialist
1 Eales disease publication
FL
Fernando Murillo López
Specialist
1 Eales disease publication
SM
Silvia Medina Medina
LAS VEGAS, NV
Specialist
1 Eales disease publication
SL
Sergio Murillo López
Specialist
1 Eales disease publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Eales disease.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Eales disease

No recent news articles for Eales disease.

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Do I need to be tested for tuberculosis, and could treating it help my eye disease?,How often do I need eye check-ups, and what signs should make me come in urgently?,Is laser treatment recommended for me now, or should we wait and monitor?,What are the risks of vision loss in my other eye, and how can we protect it?,Are there any lifestyle changes or activities I should avoid to protect my vision?,What are the side effects of the medications you are recommending, and how long will I need to take them?,Should I see a specialist in uveitis or retinal disease, and is there a center with experience in Eales disease?

Common questions about Eales disease

What is Eales disease?

Eales disease is a rare eye condition that mainly affects the blood vessels in the retina — the light-sensitive layer at the back of the eye. It was first described by British ophthalmologist Henry Eales in the 1880s. The disease causes inflammation of the retinal blood vessels (a process called retinal vasculitis), which can lead to abnormal new blood vessel growth, bleeding inside the eye, and in serious cases, vision loss. It is sometimes called idiopathic retinal vasculitis or peripheral retinal periphlebitis, because the inflammation tends to start in the outer (peripheral) parts of the r

How is Eales disease inherited?

Eales disease follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Eales disease typically begin?

Typical onset of Eales disease is adult. Age of onset can vary across affected individuals.

Which specialists treat Eales disease?

16 specialists and care centers treating Eales disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.