Overview
Distal arthrogryposis type 10 (DA10) is a rare genetic condition that mainly affects the muscles and joints, particularly those at the ends of the limbs — the hands, feet, and sometimes the face. 'Arthrogryposis' means that joints are stiff and fixed in unusual positions, often present from birth. In DA10, this stiffness tends to be milder than in some other types of arthrogryposis, but it can still significantly affect how a person moves and functions day to day. The condition is caused by changes (mutations) in the MYMK gene, which plays an important role in how muscle cells fuse together during development. When this process does not work correctly, muscles do not form properly, leading to joint contractures — joints that are stuck in a bent or straightened position. Common features include curved or overlapping fingers, clubfoot or other foot deformities, and sometimes weakness in the facial muscles, which can affect eating and expression. There is currently no cure for DA10, but treatment focuses on improving function and quality of life. Physical therapy, occupational therapy, splinting, and in some cases surgery can help improve joint movement and independence. Many people with DA10 have normal intelligence and a normal life expectancy, though they may need ongoing support to manage physical challenges.
Key symptoms:
Stiff, fixed joints in the hands and feet present from birthCurved or overlapping fingers (camptodactyly)Clubfoot or other foot deformitiesWeakness or underdevelopment of musclesFacial muscle weakness affecting expressions or eatingDifficulty opening the mouth fully (trismus)Short stature in some individualsLimited range of motion in multiple jointsThin or underdeveloped limb muscles
Autosomal recessive
Passed on when both parents carry the same gene change; often skips generations
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
1 availableXIAFLEX
The treatment of adult patients with Dupuytren's contracture with a palpable cord
Clinical Trials
View all trials with filters →No actively recruiting trials found for Distal arthrogryposis type 10 at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Distal arthrogryposis type 10.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Distal arthrogryposis type 10.
Community
No community posts yet. Be the first to share your experience with Distal arthrogryposis type 10.
Start the conversation →Latest news about Distal arthrogryposis type 10
Disease timeline:
New recruiting trial: Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy.
A new clinical trial is recruiting patients for Distal arthrogryposis type 10
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which joints are affected in my child, and how severe is the involvement?,What therapies should we start right away, and how often should they happen?,Will my child need surgery, and if so, when is the best time?,Are there other family members who should be tested for the MYMK gene change?,What school or developmental supports should we put in place?,Will the joint stiffness get worse over time, or stay the same?,Are there any clinical trials or research studies we could participate in?
Common questions about Distal arthrogryposis type 10
What is Distal arthrogryposis type 10?
Distal arthrogryposis type 10 (DA10) is a rare genetic condition that mainly affects the muscles and joints, particularly those at the ends of the limbs — the hands, feet, and sometimes the face. 'Arthrogryposis' means that joints are stiff and fixed in unusual positions, often present from birth. In DA10, this stiffness tends to be milder than in some other types of arthrogryposis, but it can still significantly affect how a person moves and functions day to day. The condition is caused by changes (mutations) in the MYMK gene, which plays an important role in how muscle cells fuse together d
How is Distal arthrogryposis type 10 inherited?
Distal arthrogryposis type 10 follows a autosomal recessive inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Distal arthrogryposis type 10 typically begin?
Typical onset of Distal arthrogryposis type 10 is neonatal. Age of onset can vary across affected individuals.
What treatment and support options exist for Distal arthrogryposis type 10?
1 patient support program are currently tracked on UniteRare for Distal arthrogryposis type 10. See the treatments and support programs sections for copay assistance, eligibility, and contact details.