Overview
Dissecting cellulitis of the scalp (also called dissecting folliculitis of the scalp, perifolliculitis capitis abscedens et suffodiens, or Hoffmann disease) is a rare, long-lasting skin condition that affects the scalp. It causes painful, pus-filled lumps and tunnels under the skin that connect different areas of the scalp. Over time, these areas can scar and lead to permanent hair loss in the affected patches. The condition happens when hair follicles become blocked and then infected or inflamed deep under the skin. This creates swollen, soft bumps that may burst and drain fluid or pus. The tunnels that form under the skin (called sinus tracts) are a hallmark of this disease. It most often affects young adult men, particularly those with darker skin tones, and it can be both physically painful and emotionally distressing. Treatment aims to reduce inflammation, control infection, and slow scarring. Options include antibiotics, isotretinoin (a strong acne-like medication), steroid injections, and in some cases surgery or laser therapy. While there is no cure, early and consistent treatment can help manage symptoms and reduce permanent hair loss. This condition is part of a group called the 'follicular occlusion tetrad,' which includes similar scarring skin diseases.
Key symptoms:
Painful, soft lumps or bumps on the scalpPus or fluid draining from bumps on the scalpTunnels or channels forming under the scalp skin connecting different bumpsPatchy hair loss on the scalpScarring on the scalp where hair no longer growsCrusting or scabbing on the scalpSwelling and redness of the scalpTenderness or soreness when touching the scalpBad smell from draining soresFirm, raised scars (keloids) forming on the scalp over time
Clinical phenotype terms (7)— hover any for plain English
Multifactorial
Caused by a mix of several genes and environmental factors
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for Dissecting cellulitis of the scalp.
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Specialists
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Dissecting cellulitis of the scalp.
Community
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Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What treatment do you recommend for my specific case, and how long will I need to take it?,Is isotretinoin a good option for me, and what are the risks and side effects I should know about?,Can any of the hair I have already lost grow back, or is it permanently gone?,Are there any newer treatments or clinical trials I should consider?,How often should I come in for follow-up appointments, and what signs should prompt me to call sooner?,Are there any lifestyle changes, hair care routines, or products I should avoid?,Should I see a mental health professional to help cope with the emotional impact of this condition?
Common questions about Dissecting cellulitis of the scalp
What is Dissecting cellulitis of the scalp?
Dissecting cellulitis of the scalp (also called dissecting folliculitis of the scalp, perifolliculitis capitis abscedens et suffodiens, or Hoffmann disease) is a rare, long-lasting skin condition that affects the scalp. It causes painful, pus-filled lumps and tunnels under the skin that connect different areas of the scalp. Over time, these areas can scar and lead to permanent hair loss in the affected patches. The condition happens when hair follicles become blocked and then infected or inflamed deep under the skin. This creates swollen, soft bumps that may burst and drain fluid or pus. The
How is Dissecting cellulitis of the scalp inherited?
Dissecting cellulitis of the scalp follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Dissecting cellulitis of the scalp typically begin?
Typical onset of Dissecting cellulitis of the scalp is adult. Age of onset can vary across affected individuals.