Overview
Dianzani autoimmune lymphoproliferative disease (also known as DALD or Dianzani autoimmune lymphoproliferative syndrome) is a rare condition that affects the immune system. In this disease, the body's immune system does not properly regulate itself, leading to an overgrowth (proliferation) of certain white blood cells called lymphocytes. Normally, the body has a built-in process called apoptosis (programmed cell death) that removes immune cells when they are no longer needed. In DALD, this process does not work correctly, so excess lymphocytes build up and can cause problems throughout the body. People with DALD may experience enlarged lymph nodes, an enlarged spleen, and autoimmune problems where the immune system mistakenly attacks the body's own healthy cells. This can lead to low blood counts, including anemia (low red blood cells), low platelet counts (which can cause easy bruising and bleeding), and low white blood cell counts (which can increase infection risk). The condition shares features with the better-known autoimmune lymphoproliferative syndrome (ALPS) but is considered a distinct entity because it involves different underlying genetic mechanisms. Treatment for DALD is mainly focused on managing symptoms and controlling the overactive immune system. Doctors may use immunosuppressive medications to calm the immune response. Regular monitoring by specialists is important to watch for complications, including a slightly increased risk of lymphoma (a type of blood cancer). Early diagnosis and ongoing care can help improve quality of life for people living with this condition.
Also known as:
Key symptoms:
Enlarged lymph nodes (swollen glands)Enlarged spleenEnlarged liverAnemia (low red blood cells causing tiredness and paleness)Low platelet count (easy bruising or bleeding)Low white blood cell count (frequent infections)Autoimmune destruction of red blood cellsAutoimmune destruction of plateletsFatigue and low energyRecurrent infectionsUnexplained feversSkin rashes related to autoimmune activity
Variable
Can be inherited in different ways depending on the underlying gene
Childhood
Begins in childhood, roughly ages 1 to 12
Treatments
No FDA-approved treatments are currently listed for Dianzani autoimmune lymphoproliferative disease.
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Specialists
View all specialists →No specialists are currently listed for Dianzani autoimmune lymphoproliferative disease.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Dianzani autoimmune lymphoproliferative disease.
Community
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Caregiver Resources
NORD Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific genetic change is causing my (or my child's) condition?,How often will blood counts need to be monitored?,What are the signs that the disease is getting worse and when should I seek emergency care?,What medications are recommended, and what are their side effects?,What is the long-term risk of developing lymphoma, and how will you screen for it?,Are there any activities or medications my child should avoid?,Should other family members be tested for this condition?
Common questions about Dianzani autoimmune lymphoproliferative disease
What is Dianzani autoimmune lymphoproliferative disease?
Dianzani autoimmune lymphoproliferative disease (also known as DALD or Dianzani autoimmune lymphoproliferative syndrome) is a rare condition that affects the immune system. In this disease, the body's immune system does not properly regulate itself, leading to an overgrowth (proliferation) of certain white blood cells called lymphocytes. Normally, the body has a built-in process called apoptosis (programmed cell death) that removes immune cells when they are no longer needed. In DALD, this process does not work correctly, so excess lymphocytes build up and can cause problems throughout the bod
At what age does Dianzani autoimmune lymphoproliferative disease typically begin?
Typical onset of Dianzani autoimmune lymphoproliferative disease is childhood. Age of onset can vary across affected individuals.