Complex regional pain syndrome

Last reviewed

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ORPHA:83452OMIM:604335G90.6G90.5
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14Active trials44Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Clinical phenotype terms— hover any for plain English:

Limb painHP:0009763Slow-growing nailsHP:0008383Edema of the upper limbsHP:0010742Trophic changes related to painHP:0010834AllodyniaHP:0012533Abnormality of hair growthHP:0040170
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

10 events
Mar 2026Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

Ambros Therapeutics, Inc. — PHASE3

TrialRECRUITING
Mar 2026Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome

Polyclinique de l'Europe — NA

TrialNOT YET RECRUITING
Jan 2026Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study

Bo Biering-Soerensen — NA

TrialRECRUITING
Dec 2025Peripersonal Space Representation in Upper Limb Segmental Exclusion

Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est

TrialRECRUITING
Sep 2025The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.

Oulu University Hospital — NA

TrialRECRUITING
Sep 2025Ultrasound and Somatosensory Median Nerve Evaluation in CRPS I

Azienda Ospedaliero-Universitaria Careggi

TrialNOT YET RECRUITING
Jul 2025Reducing Pain in Complex Regional Pain Syndrome Using Personalized Brain Stimulation: A Feasibility Study

McMaster University — NA

TrialNOT YET RECRUITING
Apr 2025Physiological Parameters in CRPS Patients Treated With Dorsal Root Ganglion Stimulation

AZ Delta — NA

TrialACTIVE NOT RECRUITING
Jan 2025CSS-SR Validation Study

Hospital for Special Surgery, New York — NA

TrialENROLLING BY INVITATION
Nov 2024Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study

University Hospital, Angers — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Complex regional pain syndrome.

14 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

14 recruitingView all trials with filters →
Phase 31 trial
Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
Phase 3
Actively Recruiting
· Sites: Phoenix, Arizona; Tucson, Arizona +2 more · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A9 trials
The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.
N/A
Actively Recruiting
PI: Jani M Takatalo, PhD, MD, PRM Specialist (Oulu University Hospital, Pain Clinic) · Sites: Oulu, North Ostrobothnia · Age: 18–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)
N/A
Actively Recruiting
PI: Aníbal Báez-Suárez, PhD (University of Las Palmas de Gran Canaria) · Sites: Las Palmas de Gran Canaria, Palmas, Las · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study
N/A
Actively Recruiting
· Sites: Glostrup, Region Sjælland · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
CSS-SR Validation Study
N/A
Enrolling by Invitation
PI: Alexandra Sideris, PhD (Hospital for Special Surgery, New York) · Sites: New York, New York · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
TMS for Complex Regional Pain Syndrome
N/A
Actively Recruiting
· Sites: Redwood City, California · Age: 18–70 yrs
View on ClinicalTrials.gov ↗I'm interested →
Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study
N/A
Actively Recruiting
· Sites: Angers; Laval · Age: 18–65 yrs
View on ClinicalTrials.gov ↗I'm interested →
Supraspinal Processing of Sensory Aspects of Pain
N/A
Actively Recruiting
PI: Robert Coghill, PhD (Children's Hospital Medical Center, Cincinnati) · Sites: Cincinnati, Ohio · Age: 10–17 yrs
View on ClinicalTrials.gov ↗I'm interested →
Physiological Parameters in CRPS Patients Treated With Dorsal Root Ganglion Stimulation
N/A
Active
· Sites: Roeselare · Age: 16–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Prednisone for CRPS in Distal Radius Fracture
N/A
Actively Recruiting
PI: David Stockton, MD, MASc, FRCSC (University of British Columbia) · Sites: Vancouver, British Columbia · Age: 19–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other4 trials
Spatially Transcriptomics Reveals Molecular Signatures in CRPS
Actively Recruiting
PI: Jee Youn Moon, MD, PhD (Seoul National University Hospital) · Sites: Seoul · Age: 19–80 yrs
View on ClinicalTrials.gov ↗I'm interested →
Peripersonal Space Representation in Upper Limb Segmental Exclusion
Actively Recruiting
· Sites: Nancy · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Forward Looking InfraRed Imaging and Severity Score in Complex Regional Pain Syndrome
Active
PI: Semih Gungor, MD (Hospital for Special Surgery, New York) · Sites: New York, New York · Age: 18–85 yrs
View on ClinicalTrials.gov ↗I'm interested →
Role of the Gut Microbiome in Complex Regional Pain Syndrome
Actively Recruiting
PI: Lara Crock, MD PhD (Washington University School of Medicine) · Sites: St Louis, Missouri · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

Showing 25 of 44View all specialists →
RM
Richard Rauck, M.D.
Specialist
PI on 1 active trial
MQ
Martine QUINTARD
Specialist
PI on 1 active trial
TS
Tolga Suvar
CHICAGO, IL
Specialist
1 Complex regional pain syndrome publication
CM
Candida S McCabe
Specialist
1 Complex regional pain syndrome publication
AP
Alexandra Sideris, PhD
New York, New York
Specialist

Rare Disease Specialist

JS
Jani M Takatalo, PhD, MD, PRM Specialist
Oulu, North Ostrobothnia
Specialist

Rare Disease Specialist

SG
Sharon Grieve
Specialist
1 Complex regional pain syndrome publication
AG
Andreas Goebel
Specialist
5 Complex regional pain syndrome publications
MF
Michael C Ferraro
Specialist
3 Complex regional pain syndrome publications
NO
Neil E O'Connell
Specialist
3 Complex regional pain syndrome publications
GM
G Lorimer Moseley
Specialist
3 Complex regional pain syndrome publications
SB
Stephen Bruehl
NASHVILLE, TN
Specialist
2 Complex regional pain syndrome publications
AC
Aidan G Cashin
Specialist
2 Complex regional pain syndrome publications
JM
James H McAuley
Specialist
2 Complex regional pain syndrome publications
OV
Omar Viswanath
PHOENIX, AZ
Specialist
2 Complex regional pain syndrome publications
RH
R Norman Harden
Specialist
1 Complex regional pain syndrome publication
BW
Benedict M Wand
Specialist
2 Complex regional pain syndrome publications
KS
Keith M Smart
GRAND RAPIDS, MI
Specialist
2 Complex regional pain syndrome publications
JM
Jeongsoo Kim, MD
Specialist
PI on 1 active trial
JP
Joy C MacDermid, PhD
Specialist
PI on 2 active trials
SM
Srinivasa N Raja, MD
BALTIMORE, MD
Specialist
PI on 1 active trial
AM
Adam Zalewski, MD
MATTHEWS, NC
Specialist
PI on 1 active trial
CP
Christian Kersten, MD PhD
Specialist
PI on 1 active trial
YP
Yannick Tousignant-Laflamme, PhD
Specialist
PI on 1 active trial
PP
Patricia Bourgault, PhD
Specialist
PI on 1 active trial

Treatment Centers

8 centers
⚗️ Trial Site

Hospital for Special Surgery

📍 New York, New York

👤 Alexandra Sideris, PhD

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Travel Grants

No travel grants are currently matched to Complex regional pain syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Complex regional pain syndrome

Disease timeline:

New trial: The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.

Phase NA trial recruiting. rTMS

New trial: CSS-SR Validation Study

Phase NA trial recruiting. Complex Regional Pain Syndrome (CRPS) Severity Score - Self Report

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Complex regional pain syndrome

Are there clinical trials for Complex regional pain syndrome?

Yes — 14 recruiting clinical trials are currently listed for Complex regional pain syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Complex regional pain syndrome?

25 specialists and care centers treating Complex regional pain syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.