Combined hamartoma of the retina and retinal pigment epithelium

Combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) is a rare, non-cancerous growth that forms in the back of the eye. It involves an abnormal mix of retinal tissue and the pigment layer beneath it (called the retinal pigment epithelium). These growths are benign tumors, meaning they are not cancer, but they can still cause significant vision problems depending on where they form and how large they grow. The condition is also sometimes called combined retinal hamartoma or CHRRPE for short. The hamartoma typically appears as a slightly raised, grayish or pigmented lesion on the retina. When it grows near the center of the retina (the macula) or involves the optic nerve, it can distort or reduce vision. Some people notice that straight lines look wavy or bent — a symptom called metamorphopsia. Others may experience reduced sharpness of vision or a blind spot. In some cases, the condition is discovered during a routine eye exam with no symptoms at all. CHRRPE is often diagnosed in children and young adults, though it can be found at any age. It is sometimes associated with other conditions, most notably neurofibromatosis type 2 (NF2), a genetic disorder affecting the nervous system. Treatment focuses on monitoring the lesion and managing complications such as fluid buildup or membrane formation on the retina. There is no cure, but many people maintain useful vision with careful follow-up care.

Bring these to your next appointment

• Q1.Where exactly is the hamartoma located in my eye, and how does that affect my vision outlook?,Should I be tested for neurofibromatosis type 2, and should my family members be evaluated?,How often do I need follow-up eye exams, and what imaging will be done each visit?,What warning signs should prompt me to call you or go to the emergency room right away?,Are there any treatments that could help if my vision gets worse over time?,If I have a child with this condition, what vision support or school accommodations should I arrange?,Are there any clinical trials or research studies I should know about?

Common questions about Combined hamartoma of the retina and retinal pigment epithelium