Chronic hiccup

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ORPHA:396G25.8
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8Treatment centers1Financial resources

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Overview

Chronic hiccup, also called intractable hiccup or persistent hiccup, is a condition where a person has hiccups that last for more than 48 hours — and in some cases, for weeks, months, or even years. While most people think of hiccups as a harmless annoyance that goes away on its own, chronic hiccups are a recognized medical condition that can seriously affect a person's quality of life. The hiccup reflex involves a sudden, involuntary contraction of the diaphragm (the large breathing muscle under your lungs), followed by a quick closure of the vocal cords, which creates the familiar 'hic' sound. Chronic hiccups can be caused by many different things, including irritation of the nerves that control the diaphragm (especially the vagus and phrenic nerves), problems in the brain or brainstem, gastrointestinal issues like acid reflux, certain medications, metabolic imbalances, or serious underlying conditions like tumors or infections. Sometimes no clear cause is found. Symptoms go beyond just the hiccup sound — people often experience exhaustion, difficulty eating, trouble sleeping, weight loss, and emotional distress. Treatment depends on the underlying cause and may include medications, nerve blocks, or treating the root problem. With proper care, many people find relief, though some cases remain difficult to manage.

Key symptoms:

Hiccups lasting more than 48 hours without stoppingDifficulty sleeping due to constant hiccupingTrouble eating or swallowingUnintended weight lossFatigue and exhaustion from ongoing hiccupsChest discomfort or painHeartburn or acid refluxAnxiety, frustration, or depression related to the conditionDifficulty speaking or holding a conversationNausea

Clinical phenotype terms (8)— hover any for plain English
Recurrent singultusHP:0100247Abnormality of the diaphragmHP:0000775Abnormal eating behaviorHP:0100738
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Chronic hiccup.

View clinical trials →

No actively recruiting trials found for Chronic hiccup at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Chronic hiccup community →

No specialists are currently listed for Chronic hiccup.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Financial Resources

1 resources

CETIRIZINE HYDROCHLORIDE

UCB

Chronic Hives

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copay card
Copay CardPatient Assistance
Accepting applications

Travel Grants

No travel grants are currently matched to Chronic hiccup.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Chronic hiccup

No recent news articles for Chronic hiccup.

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.What do you think is causing my chronic hiccups, and what tests do I need?,Which medications are most likely to help me, and what are the side effects?,How long might it take before I see improvement with treatment?,Are there any lifestyle changes or triggers I should avoid?,Should I see any other specialists, such as a neurologist or gastroenterologist?,What should I do if my hiccups get much worse or I develop new symptoms?,Are there any clinical trials or newer treatments I should know about?

Common questions about Chronic hiccup

What is Chronic hiccup?

Chronic hiccup, also called intractable hiccup or persistent hiccup, is a condition where a person has hiccups that last for more than 48 hours — and in some cases, for weeks, months, or even years. While most people think of hiccups as a harmless annoyance that goes away on its own, chronic hiccups are a recognized medical condition that can seriously affect a person's quality of life. The hiccup reflex involves a sudden, involuntary contraction of the diaphragm (the large breathing muscle under your lungs), followed by a quick closure of the vocal cords, which creates the familiar 'hic' soun

How is Chronic hiccup inherited?

Chronic hiccup follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

What treatment and support options exist for Chronic hiccup?

1 patient support program are currently tracked on UniteRare for Chronic hiccup. See the treatments and support programs sections for copay assistance, eligibility, and contact details.