Overview
Chronic hiccup, also called intractable hiccup or persistent hiccup, is a condition where a person has hiccups that last for more than 48 hours — and in some cases, for weeks, months, or even years. While most people think of hiccups as a harmless annoyance that goes away on its own, chronic hiccups are a recognized medical condition that can seriously affect a person's quality of life. The hiccup reflex involves a sudden, involuntary contraction of the diaphragm (the large breathing muscle under your lungs), followed by a quick closure of the vocal cords, which creates the familiar 'hic' sound. Chronic hiccups can be caused by many different things, including irritation of the nerves that control the diaphragm (especially the vagus and phrenic nerves), problems in the brain or brainstem, gastrointestinal issues like acid reflux, certain medications, metabolic imbalances, or serious underlying conditions like tumors or infections. Sometimes no clear cause is found. Symptoms go beyond just the hiccup sound — people often experience exhaustion, difficulty eating, trouble sleeping, weight loss, and emotional distress. Treatment depends on the underlying cause and may include medications, nerve blocks, or treating the root problem. With proper care, many people find relief, though some cases remain difficult to manage.
Key symptoms:
Hiccups lasting more than 48 hours without stoppingDifficulty sleeping due to constant hiccupingTrouble eating or swallowingUnintended weight lossFatigue and exhaustion from ongoing hiccupsChest discomfort or painHeartburn or acid refluxAnxiety, frustration, or depression related to the conditionDifficulty speaking or holding a conversationNausea
Clinical phenotype terms (8)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Chronic hiccup.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Chronic hiccup at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Chronic hiccup.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesCETIRIZINE HYDROCHLORIDE
UCB
Chronic Hives
Travel Grants
No travel grants are currently matched to Chronic hiccup.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What do you think is causing my chronic hiccups, and what tests do I need?,Which medications are most likely to help me, and what are the side effects?,How long might it take before I see improvement with treatment?,Are there any lifestyle changes or triggers I should avoid?,Should I see any other specialists, such as a neurologist or gastroenterologist?,What should I do if my hiccups get much worse or I develop new symptoms?,Are there any clinical trials or newer treatments I should know about?
Common questions about Chronic hiccup
What is Chronic hiccup?
Chronic hiccup, also called intractable hiccup or persistent hiccup, is a condition where a person has hiccups that last for more than 48 hours — and in some cases, for weeks, months, or even years. While most people think of hiccups as a harmless annoyance that goes away on its own, chronic hiccups are a recognized medical condition that can seriously affect a person's quality of life. The hiccup reflex involves a sudden, involuntary contraction of the diaphragm (the large breathing muscle under your lungs), followed by a quick closure of the vocal cords, which creates the familiar 'hic' soun
How is Chronic hiccup inherited?
Chronic hiccup follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
What treatment and support options exist for Chronic hiccup?
1 patient support program are currently tracked on UniteRare for Chronic hiccup. See the treatments and support programs sections for copay assistance, eligibility, and contact details.