Cat-scratch disease

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ORPHA:50839A28.1
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16Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Cat-scratch disease (CSD), also called cat-scratch fever or benign lymphoreticulosis, is an infection caused by a bacterium called Bartonella henselae. Despite the name, it is not a genetic disease — it is an infectious illness that most people get after being scratched, bitten, or licked by a cat, especially a kitten. Fleas that live on cats spread the bacteria between cats, and when a cat scratches or bites a person, the bacteria can enter the skin. After infection, the body's immune system reacts by causing swelling in the lymph nodes — the small glands found in the neck, armpits, and groin. Most people develop a small bump or blister at the site of the scratch, followed by swollen, tender lymph nodes nearby. Other common symptoms include mild fever, tiredness, and headache. In most healthy people, the illness is mild and goes away on its own within a few weeks to months. In rare cases, especially in people with weakened immune systems, CSD can become serious and affect the eyes, liver, spleen, brain, or heart. Treatment usually involves antibiotics such as azithromycin, which can help shorten the illness. Most people recover fully with or without treatment, making the overall outlook very good for healthy individuals.

Also known as:

Key symptoms:

Swollen, tender lymph nodes (glands), especially in the neck, armpit, or groinSmall bump, blister, or sore at the site of a cat scratch or biteLow-grade feverTiredness and general feeling of being unwellHeadacheLoss of appetiteSore throatRash in some casesEye redness or swelling if bacteria enter through the eye (Parinaud's oculoglandular syndrome)Stomach pain if the liver or spleen is involvedConfusion or seizures in very rare, severe cases

Clinical phenotype terms (22)— hover any for plain English
MalaiseHP:0033834PanuveitisHP:0012121Branch retinal artery occlusionHP:0020161Branch retinal vein occlusionHP:0020165RetinitisHP:0032118Optic neuritisHP:0100653
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Cat-scratch disease.

View clinical trials →

No actively recruiting trials found for Cat-scratch disease at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Cat-scratch disease community →

Specialists

16 foundView all specialists →
HT
Hidehiro Tsuneoka
Specialist
2 Cat-scratch disease publications
IM
Ikechukwu Benjamin Moses
Specialist
1 Cat-scratch disease publication
KF
Kartika Afrida Fauzia
Specialist
1 Cat-scratch disease publication
GP
Guillaume MARTIN-BLONDEL, MD, PhD
Specialist
PI on 1 active trial
WT
Wiwiek Tyasningsih
Specialist
1 Cat-scratch disease publication
KR
Katty Hendriana Priscilia Riwu
Specialist
1 Cat-scratch disease publication
RA
Riza Zainuddin Ahmad
Specialist
1 Cat-scratch disease publication
SY
Sheila Marty Yanestria
Specialist
1 Cat-scratch disease publication
SW
Syahputra Wibowo
Specialist
1 Cat-scratch disease publication
DK
Dea Anita Ariani Kurniasih
Specialist
1 Cat-scratch disease publication
MK
Muhammad Khaliim Jati Kusala
Specialist
1 Cat-scratch disease publication
YP
Yulianna Puspitasari
Specialist
1 Cat-scratch disease publication
BW
Bantari Wisynu Kusuma Wardhani
Specialist
1 Cat-scratch disease publication
AK
Aswin Rafif Khairullah
Specialist
1 Cat-scratch disease publication
HR
Hartanto Mulyo Raharjo
Specialist
1 Cat-scratch disease publication
IF
Ima Fauziah
Specialist
1 Cat-scratch disease publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Cat-scratch disease.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Cat-scratch diseaseForum →

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Latest news about Cat-scratch disease

No recent news articles for Cat-scratch disease.

Follow this condition to be notified when news becomes available.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Do I need antibiotics, or will this get better on its own?,How long will the swollen lymph nodes last, and when should I be concerned?,Are there any signs of complications I should watch for at home?,Is it safe to keep my cat, and how can I prevent this from happening again?,Do other members of my household — especially anyone with a weakened immune system — need to take any precautions?,Should I follow up with any specialist, such as an eye doctor or infectious disease specialist?,When can my child return to school or normal activities?

Common questions about Cat-scratch disease

What is Cat-scratch disease?

Cat-scratch disease (CSD), also called cat-scratch fever or benign lymphoreticulosis, is an infection caused by a bacterium called Bartonella henselae. Despite the name, it is not a genetic disease — it is an infectious illness that most people get after being scratched, bitten, or licked by a cat, especially a kitten. Fleas that live on cats spread the bacteria between cats, and when a cat scratches or bites a person, the bacteria can enter the skin. After infection, the body's immune system reacts by causing swelling in the lymph nodes — the small glands found in the neck, armpits, and groi

How is Cat-scratch disease inherited?

Cat-scratch disease follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Which specialists treat Cat-scratch disease?

16 specialists and care centers treating Cat-scratch disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.