Overview
Cat-scratch disease (CSD), also called cat-scratch fever or benign lymphoreticulosis, is an infection caused by a bacterium called Bartonella henselae. Despite the name, it is not a genetic disease — it is an infectious illness that most people get after being scratched, bitten, or licked by a cat, especially a kitten. Fleas that live on cats spread the bacteria between cats, and when a cat scratches or bites a person, the bacteria can enter the skin. After infection, the body's immune system reacts by causing swelling in the lymph nodes — the small glands found in the neck, armpits, and groin. Most people develop a small bump or blister at the site of the scratch, followed by swollen, tender lymph nodes nearby. Other common symptoms include mild fever, tiredness, and headache. In most healthy people, the illness is mild and goes away on its own within a few weeks to months. In rare cases, especially in people with weakened immune systems, CSD can become serious and affect the eyes, liver, spleen, brain, or heart. Treatment usually involves antibiotics such as azithromycin, which can help shorten the illness. Most people recover fully with or without treatment, making the overall outlook very good for healthy individuals.
Also known as:
Key symptoms:
Swollen, tender lymph nodes (glands), especially in the neck, armpit, or groinSmall bump, blister, or sore at the site of a cat scratch or biteLow-grade feverTiredness and general feeling of being unwellHeadacheLoss of appetiteSore throatRash in some casesEye redness or swelling if bacteria enter through the eye (Parinaud's oculoglandular syndrome)Stomach pain if the liver or spleen is involvedConfusion or seizures in very rare, severe cases
Clinical phenotype terms (22)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Cat-scratch disease.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Cat-scratch disease at this time.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Cat-scratch disease.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Do I need antibiotics, or will this get better on its own?,How long will the swollen lymph nodes last, and when should I be concerned?,Are there any signs of complications I should watch for at home?,Is it safe to keep my cat, and how can I prevent this from happening again?,Do other members of my household — especially anyone with a weakened immune system — need to take any precautions?,Should I follow up with any specialist, such as an eye doctor or infectious disease specialist?,When can my child return to school or normal activities?
Common questions about Cat-scratch disease
What is Cat-scratch disease?
Cat-scratch disease (CSD), also called cat-scratch fever or benign lymphoreticulosis, is an infection caused by a bacterium called Bartonella henselae. Despite the name, it is not a genetic disease — it is an infectious illness that most people get after being scratched, bitten, or licked by a cat, especially a kitten. Fleas that live on cats spread the bacteria between cats, and when a cat scratches or bites a person, the bacteria can enter the skin. After infection, the body's immune system reacts by causing swelling in the lymph nodes — the small glands found in the neck, armpits, and groi
How is Cat-scratch disease inherited?
Cat-scratch disease follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Cat-scratch disease?
16 specialists and care centers treating Cat-scratch disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.