Benign idiopathic neonatal seizures

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Overview

Benign idiopathic neonatal seizures (BINS), also known as 'fifth-day fits,' are a type of seizure that occurs in otherwise healthy newborns, typically in the first week of life. The word 'benign' means that these seizures are not caused by a serious underlying brain problem and usually go away on their own without causing lasting harm. 'Idiopathic' means that no clear cause, such as infection, low blood sugar, or brain injury, can be found to explain why the seizures happen. The seizures usually begin between the fourth and sixth day after birth, which is why they are sometimes called 'fifth-day fits.' They can look alarming — a baby may have jerking movements, stiffening of the body, or brief pauses in breathing — but they typically last only a short time. Most babies have multiple seizures over one to three days, and then the seizures stop on their own. The good news is that most babies with this condition go on to develop completely normally. Doctors will run tests to rule out other causes of seizures before making this diagnosis. Treatment is usually short-term, and many babies do not need long-term anti-seizure medication. The outlook for children with this condition is generally excellent.

Also known as:

Key symptoms:

Jerking or twitching movements of the arms, legs, or faceStiffening of the bodyBrief pauses in breathing (apnea)Eye deviation or flickering eye movementsLip smacking or sucking movementsSudden limpnessRepeated seizures over one to three daysSeizures beginning between day four and day six of lifeNormal behavior and alertness between seizures

Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Benign idiopathic neonatal seizures.

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No actively recruiting trials found for Benign idiopathic neonatal seizures at this time.

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No specialists are currently listed for Benign idiopathic neonatal seizures.

View NORD Rare Disease Centers ↗Undiagnosed Disease Network ↗

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Benign idiopathic neonatal seizures.

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Community

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Questions for your doctor

Bring these to your next appointment

  • Q1.Are you confident that all other causes of seizures have been ruled out in my baby?,Does my baby need to continue anti-seizure medication after going home, and for how long?,What are the chances that my baby will have seizures again later in childhood?,Will this affect my baby's development, learning, or behavior as they grow up?,What signs should I watch for at home that would mean I need to call for emergency help?,How often should my baby be seen for follow-up, and by which specialist?,Is there any genetic testing I should consider, especially if we plan to have more children?

Common questions about Benign idiopathic neonatal seizures

What is Benign idiopathic neonatal seizures?

Benign idiopathic neonatal seizures (BINS), also known as 'fifth-day fits,' are a type of seizure that occurs in otherwise healthy newborns, typically in the first week of life. The word 'benign' means that these seizures are not caused by a serious underlying brain problem and usually go away on their own without causing lasting harm. 'Idiopathic' means that no clear cause, such as infection, low blood sugar, or brain injury, can be found to explain why the seizures happen. The seizures usually begin between the fourth and sixth day after birth, which is why they are sometimes called 'fifth-

How is Benign idiopathic neonatal seizures inherited?

Benign idiopathic neonatal seizures follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Benign idiopathic neonatal seizures typically begin?

Typical onset of Benign idiopathic neonatal seizures is neonatal. Age of onset can vary across affected individuals.