Clinical trials for Adult hepatocellular carcinoma
100 recruiting or active trials synced from ClinicalTrials.gov.
ℹ
Clinical trial records are synced from ClinicalTrials.gov through automated extraction.
Report missing data- ENROLLING BY INVITATIONPhase 2NCT07441369Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases CancerFudan University
- RECRUITINGPhase 2NCT07175441Evaluation of RBS2418 in Combination With Tremelimumab Plus Durvalumab in Participants With Advanced Unresectable Hepatocellular CarcinomaRiboscience, LLC.
- RECRUITINGPhase 2NCT07560488Ipilimumab N01 Combined With Sintilimab, Bevacizumab Biosimilar, and Hepatic Arterial Infusion Chemotherapy as Conversion Therapy for Unresectable Intermediate-Advanced Hepatocellular CarcinomaTianjin Medical University Cancer Institute and Hospital
- RECRUITINGPhase 2NCT07010497A Prospective Study to Evaluate the Safety and Efficacy of the Combination Therapy of Irpagratinib, Atezolizumab, and Bevacizumab in Patients With Hepatocellular CarcinomaAsan Medical Center
- RECRUITINGPHASE1, PHASE2NCT07291076A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)Bristol-Myers Squibb · PI: Bristol-Myers Squibb
- RECRUITINGPHASE1, PHASE2NCT07500220Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCCBeijing Biotech
- RECRUITINGPhase 2NCT07413354Tislelizumab Combined With Huaier Granule as First-line Treatment for Unresectable Hepatocellular CarcinomaTongji Hospital
- RECRUITINGN/ANCT07365527Sonoporation and Tumor Microenvironment Response in Colorectal Liver MetastasesZealand University Hospital · PI: Christian P Nolsøe, Professor
- RECRUITINGN/ANCT07445386Transdiscal vs Paravertebral Neurolytic Splanchnic Nerve Block for Upper Abdominal Cancer PainAnkara Etlik City Hospital · PI: Gokhan Yildiz
- RECRUITINGPhase 1NCT07337525A First in Human Study of PLT012 in Participants With Solid Tumor CancersPilatus Biosciences Inc · PI: Anthony El-Khoueiry, MD
- ACTIVE NOT RECRUITINGN/ANCT07493070Ultra-stable Iodized Oil-Chemo Embolization Seq Thermal Ablation in Early Liver CaFujian Medical University Union Hospital
- RECRUITINGPhase 3NCT07417397Adjuvant TACE in HCC With High-risk Recurrence FactorsGuangxi Medical University · PI: Jian-Hong Zhong
- RECRUITINGNCT07351669A Multicenter Prospective Study on the Performance of Spectral CT for Evaluating Treatment Response After TACE in Hepatocellular CarcinomaZhongda Hospital
- RECRUITINGPhase 2NCT07174570Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver CancerEmory University · PI: Olumide B. Gbolahan, MBBS, MSc
- RECRUITINGEarly Phase 1NCT07295262NIR-II Fluorescence-Guided Hepatectomy Using ICG-Cisplatin Nanoprobes for HCCWest China Hospital
- RECRUITINGPhase 2NCT07312292Radioembolization With Intra-arterial Angiotensin II to Improve Tumor-absorbed Dose (RADIANT)Niek Wijnen
- RECRUITINGNCT07291141A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver CirrhosisMattias Ekstedt · PI: Mattias Ekstedt, MD, PhD
- RECRUITINGN/ANCT07243691Study on the Therapeutic Effect of Different Infusion Times of Tislelizumab on Postoperative High-risk Hepatocellular CarcinomaSir Run Run Shaw Hospital
- RECRUITINGPHASE1, PHASE2NCT07227012A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.Pfizer · PI: Pfizer CT.gov Call Center
- RECRUITINGPhase 1NCT07176650Phase I Clinical Study To Evaluate Pharmacokinetic Profile, Safety, Efficacy and Immunogenicity Of Ipilimumab Biosimilar HLX13 Vs. YERVOY® (US-Sourced YERVOY®) As A First-Line Treatment For Patients With Unresectable Hepatocellular CarcinomaShanghai Henlius Biotech
- RECRUITINGN/ANCT06681818Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial HepatectomyEnglewood Hospital and Medical Center · PI: Cherif Boutros, MD
- RECRUITINGPHASE1, PHASE2NCT06811116Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE TrialNational Cancer Institute (NCI) · PI: Anwaar Saeed
- RECRUITINGN/ANCT07428356Histotripsy for Ablation of Liver Tumours in AsiaNational Cancer Centre, Singapore · PI: Prof Brian Goh, MBBS, MMed, MSc, FRCSEd, FAMS
- RECRUITINGPhase 1NCT07053072PD-1 mRNA LNP Vaccine for Advanced Primary Hepatocellular Carcinoma.West China Hospital · PI: Xingchen Peng
- RECRUITINGPHASE2, PHASE3NCT07285850The Efficacy of Sequential Treatment With Bevacizumab Combined With Atezolizumab in Advanced Liver Cancer With MASLDEastern Hepatobiliary Surgery Hospital
- RECRUITINGPhase 2NCT07111546A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours[Substudy 02(BTC&HCC)]Nanjing Leads Biolabs Co.,Ltd · PI: Jian zhou
- RECRUITINGPhase 3NCT07166406Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT TrialNRG Oncology
- RECRUITINGN/ANCT07395635Phase II Trial of Immunonutrition in HepatectomyTata Memorial Centre · PI: Dr. Shraddha Patkar, MD MCh
- RECRUITINGNCT07315633An Innovative CFD-based Dosimetry and Pre-treatment Planning Platform to Support Personalized Transarterial Therapies for Liver CancerUniversity Hospital, Ghent
- RECRUITINGPhase 2NCT07145801Y-90 Treatment Response Using Transarterial RadioembolizationThomas Jefferson University · PI: John Eisenbrey, PhD
- RECRUITINGNCT07147101Different First-line Immunotherapy for Advancer Hepatocellular Carcinoma: A Prospective Observational Study on Efficacy and Immune MicroenvironmentFudan University
- RECRUITINGPhase 2NCT07337421Efcacy and Safety of Postoperative Adjuvant Hepatic Arterial Infusion Chemotherapy With mFOLFOX in Hepatocellular Carcinoma With High-risk Recurrence FactorsNorthern Jiangsu People's Hospital · PI: Dou-sheng Bai
- RECRUITINGPhase 4NCT07150624The Treatment of Liver Injury After Liver Resection With Polyene PhosphatidylcholineAnhui Provincial Hospital
- RECRUITINGPhase 2NCT07334483A Study of Yttrium [90Y] Microsphere Injection in Combination With Targeted Immunotherapy in the Treatment of HCCGrandPharma (China) Co., Ltd. · PI: Zhiping Yan, MD
- RECRUITINGNCT07100405TACE Combined With Anti-PD-1 Antibody in Patients With Advanced Hepatocellular Carcinoma: Study on Efficacy and Immune MicroenvironmentFudan University
- RECRUITINGPhase 2NCT07100392Tauroursodeoxycholic Acid (TUDCA) Plus Camrelizumab and Regorafenib in Hepatocellular Carcinoma Previously Treated With Anti-PD1/PD-L1 and BevacizumabFudan University
- ACTIVE NOT RECRUITINGNCT05613621Dissection of the Molecular and Immunological Interaction in Patients With HCC of Viral and Non-viral EtiologiesNational Health Research Institutes, Taiwan · PI: Tsang-Wu Liu
- RECRUITINGPhase 1NCT07391839MDN-001 Injection for the Treatment of Unresectable Primary Hepatocellular Carcinoma.Suzhou Mednovo Yi Medical Technology Co., Ltd.
- RECRUITINGN/ANCT06824974To Test Whether Time-restricted Eating Coupled With a Healthy Diet is Beneficial in Liver Cancer PatientsUniversity of California, San Diego · PI: Nick Webster, PhD
- RECRUITINGPhase 1NCT07077356Application of mRNA Vaccine in Liver Transplantation for Hepatocellular CarcinomaWest China Hospital
- RECRUITINGNCT07345247RAdiation SEgmentectomy With REsin Microspheres (RASEREM) StudyAnkara University
- RECRUITINGPhase 2NCT07062055BITS-TO-HCC Study: HAIC+Iparomlimab/Tuvonralimab + Bevacizumab + SBRT for BCLC-C HCC With PVTT and/or OligometastasesShandong Cancer Hospital and Institute · PI: Jinbo Yue, Doctor
- RECRUITINGPHASE1, PHASE2NCT07070518Study of GV20-0251 in Participants With Solid Tumor MalignanciesGV20 Therapeutics
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT07034950Effective Dose and Safety of Esketamine During Ultrasound-guided Hepatic Tumor Thermal AblationThe First Affiliated Hospital of Xiamen University · PI: Lijuan Yan
- RECRUITINGN/ANCT07039201A Study to Evaluate CG-102-12C in Glypican-3 (GPC3) Positive Advanced Hepatocellular Carcinoma (HCC)Zhejiang University
- RECRUITINGPhase 1NCT07018518PIN in Combination With Anti-PD1 in Previously Treated Primary Hepatocellular CarcinomaChinese PLA General Hospital · PI: Weidong Han, Ph.D
- RECRUITINGPhase 1NCT06198296Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T CellsBaylor College of Medicine · PI: Premal Lulla, MD
- RECRUITINGPhase 2NCT07014150Neoadjuvant Therapy of iIparomlimab and Tuvonralimab Combined With Lenvatinib for Hepatocellular CarcinomaPeking Union Medical College Hospital
- RECRUITINGPhase 2NCT06954467JS207 Combined With JS007 as First-line Treatment for Advanced Hepatocellular CarcinomaShanghai Junshi Bioscience Co., Ltd.
- RECRUITINGPhase 2NCT06999694Proton Radiotherapy Plus Tremelimumab/Durvalumab for BCLC Stage B and C HCCChang Gung Memorial Hospital
- RECRUITINGNCT06877637On-treatment Surveillance of Tumor Evolution and Response to Systemic Treatment in Bile Duct and Liver CancerRegion Skane · PI: Karin Jirström, PhD, MD, professor
- RECRUITINGNCT06999174Multiparametric MRI for Characterization of Hepatocellular CarcinomaUniversity Hospital Muenster
- RECRUITINGPhase 2NCT06605664Hyperpolarized 13C-MRI in Patients With Hepatocellular Carcinoma Undergoing Radiotherapy, Atezolizumab, and BevacizumabChang Gung Memorial Hospital
- RECRUITINGPhase 1NCT06915753Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway AberrationsTyra Biosciences, Inc · PI: Doug Warner, MD
- RECRUITINGPHASE1, PHASE2NCT06911255Safety and Efficacy of Tremelimumab+Durvalumab(MEDI4736)+TACE in Unresectable Hepatocellular CarcinomaYoon Jun Kim · PI: Yoon Jun Kim, MD, PhD
- RECRUITINGN/ANCT06909708SIRT Versus cTACE for Unresectable HCC (CHANCE2506)Zhongda Hospital · PI: Gao-Jun Teng
- RECRUITINGPhase 2NCT06904183Lenvatinib, Sintilimab, and DEB-TACE With/Without HAIC for HCC >7 cm With PVTTSecond Affiliated Hospital of Guangzhou Medical University · PI: Kangshun Zhu, Dr.
- RECRUITINGPhase 2NCT06904196Lenvatinib Plus SIRT vs Lenvatinib in TACE-Refractory HCCSecond Affiliated Hospital of Guangzhou Medical University · PI: Mingyue Cai, Dr.
- RECRUITINGPHASE1, PHASE2NCT06795022First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid TumoursAstraZeneca
- RECRUITINGPhase 2NCT06792695A Study of Novel Study Interventions and Combinations in Participants With Colorectal CancerAstraZeneca
- RECRUITINGPhase 2NCT06551272Microbiota Modification for Immuno-oncology in Hepatocellular CarcinomaCenter Eugene Marquis · PI: Héloise BOURIEN, Dr
- ACTIVE NOT RECRUITINGPHASE1, PHASE2NCT06521567A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With CancerGlaxoSmithKline · PI: GSK Clinical Trials
- RECRUITINGPHASE1, PHASE2NCT06741020Hepatic Arterial Infusion Chemotherapy and Immunotherapy for Hepatocellular CarcinomaZhejiang Cancer Hospital
- RECRUITINGNCT07265271A Cell-free tsRNA Signature for Early Detection of Hepatocellular CarcinomaCity of Hope Medical Center
- ACTIVE NOT RECRUITINGPhase 1NCT06757881IL1RAP-targeting Chimeric Antigen Receptor T Cells in the Treatment of Relapsed/Refractory Hepatocellular CarcinomaShanghai Zhongshan Hospital
- RECRUITINGPhase 1NCT06883539A Phase I Study of LXP1788 Injection with Advanced Solid Tumors.LaunXP Biomedical Co., Ltd.
- RECRUITINGPhase 2NCT06698250Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)Anwaar Saeed · PI: Anwaar M Saeed, MD
- RECRUITINGN/ANCT06740370TACE Combined With Lenvatinib and PD-1 Inhibitor for Ruptured Hepatocellular CarcinomaSun Yat-sen University · PI: Feng Duan, MD
- RECRUITINGN/ANCT06537193Abbreviated MRI Using Gadoxetic Acid Versus CT for Surveillance of Recurrent HCC After Curative TreatmentAsan Medical Center · PI: So Yeon Kim, MD, PhD
- RECRUITINGNCT06746194The Value of 68Ga-FAPI PET/CT in the Efficacy Evaluation of Advanced Unresectable Hepatocellular Carcinoma Patients Undergoing Systemic Antitumor TherapyRuijin Hospital
- RECRUITINGNCT06813508Prognostic Factors for HCC and Liver Transplantation in Patients With MASLD/MASHIRCCS Azienda Ospedaliero-Universitaria di Bologna · PI: Fabio Piscaglia, Prof, MD
- RECRUITINGPhase 1NCT06689540Mts105 for Advanced Hepatocellular CarcinomaShen Lin
- RECRUITINGNCT07036874Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular CarcinomaChinese University of Hong Kong · PI: Jimmy CT Lai, MB ChB
- RECRUITINGN/ANCT06689670Needle-based Percutaneous Ablation of Liver Tumors.inTumo Therapeutics, Inc. · PI: Fatih Selcukbiricik, MD
- RECRUITINGPhase 2NCT06558227Study of ZG005 Combined With Bevacizumab Versus Sintilimab Combined With Bevacizumab in Advanced Hepatocellular CarcinomaSuzhou Zelgen Biopharmaceuticals Co.,Ltd · PI: Jason Wu
- RECRUITINGN/ANCT06718153Immunohistochemical Algorithm for the Diagnosis and Classification of Hepatocellular Carcinomas With TERT, TP53 and CTNNB1 MutationIRCCS Azienda Ospedaliero-Universitaria di Bologna · PI: Francesco Vasuri, MD
- RECRUITINGPhase 4NCT06353126DEB-TACE Prior to Liver Transplantation in the Treatment of HCCRenJi Hospital · PI: Jianjun Zhang, MD
- RECRUITINGPhase 2NCT06664996Sintilimab Combined SBRT As Neoadjuvant Therapy for Resectable HCC with PVTTWest China Hospital
- RECRUITINGEarly Phase 1NCT06418659A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC PatientsShanghai Changzheng Hospital · PI: Wei-Fen Xie, M.D.
- RECRUITINGN/ANCT06609876Donafenib as Adjuvant Therapy Following Ablation for Recurrent HCCSun Yat-sen University · PI: Feng Duan, Professor
- RECRUITINGNCT06829290Influence of Sarcopenia on the Course of the DiseasesUniversitatsmedizin Mainz - 1. Medizinische Klinik
- RECRUITINGN/ANCT06609850The Comparison of TACE-Lenvatinib With TACE-Lenvatinib-ablation for Intermediate Recurrent Hepatocellular CarcinomaSun Yat-sen University · PI: Feng Duan
- RECRUITINGNCT06569498Neoadjuvant Triple Therapy for Resectable HCCFujian Provincial Hospital
- RECRUITINGNCT06602011Triple Therapy for Intermediate-advanced HCC With BDTT (TALENP002)Fujian Provincial Hospital
- RECRUITINGNCT06632093HAIC in Combination with PD-1 Inhibitors and Lenvatinib for Intermediate and Advanced HCC After the Failure of Systemic Therapy Recommended by BCLCFirst Hospital of China Medical University
- RECRUITINGNCT06777628Immunophenotype of PBMC to Early Predict Response to Immunotherapy in Hepatocellular CarcinomaIRCCS Azienda Ospedaliero-Universitaria di Bologna · PI: Laura Gramantieri
- RECRUITINGPhase 1NCT06487559A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in Combination With Budigalimab Moves Through the Bodies of Adult Chinese Participants With Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC)AbbVie · PI: ABBVIE INC.
- RECRUITINGPhase 2NCT05733598Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCCReplimune Inc. · PI: May Cho, MD
- RECRUITINGNCT07303712Liquid Biopsy for Hepatocellular Carcinoma Molecular Characterization After Y90Palo Alto Veterans Institute for Research · PI: Sirish Kishore, MD
- RECRUITINGNCT06536998Exploring the Association of Imaging and Tumor Microenvironment in Liver Cancer Using Radiogenomic Approach（Radiogenomics-Liver）Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- RECRUITINGPhase 2NCT06309485Phase 2 Study of WGI-0301 for Advanced HCCZhejiang Haichang Biotech Co., Ltd.
- RECRUITINGPhase 2NCT05705492Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung CancerOHSU Knight Cancer Institute · PI: Eric Roeland, M.D., FAAHPM, FASCO
- RECRUITINGNCT06590948Clinical Application of Quantitative Major Imaging Features of CEUS LI-RADSSecond Affiliated Hospital, School of Medicine, Zhejiang University
- RECRUITINGNCT06623474Correlation Study of Lipid Metabolites as Markers of Hepatocellular CarcinomaNanfang Hospital, Southern Medical University
- ENROLLING BY INVITATIONNCT06710314A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome Radical Resection of Colorectal CancerDong Peng
- RECRUITINGNCT06430983Recurrent Liver Cancer: Reconceptualization and ReevaluationNanjing Medical University · PI: zhang yewei, doctor
- RECRUITINGPhase 1NCT06478693A Study of MT-303 in Adults With Advanced or Metastatic GPC3-Expressing Cancers, Including HCCMyeloid Therapeutics · PI: Matthew Maurer, MD
- RECRUITINGPhase 2NCT06482801Checkpoint Inhibitor Combinations Therapy as First Line for HCC Via ITSecond Affiliated Hospital of Guangzhou Medical University · PI: Zhenfeng Zhang, MD, PhD
- RECRUITINGPhase 1NCT06374485Study of AU409 Capsule in Advanced Hepatocellular Carcinoma Patients Who Failed Standard TreatmentLee's Pharmaceutical Limited
- RECRUITINGNCT06447727Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLMZhongda Hospital · PI: Gao-Jun Teng